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Dr Amy Osborne

Contact

Department: School of Biological Sciences

Email: amy.osborne@canterbury.ac.nz

Direct Dial: +64 3 3692532

Office: Julius Von Haast Rm 531

Language: English

About
Research / Creative works
Networks

Fields of Research

  • Environmental epigenetics
  • DNA methylation
  • Genome regulation
  • Developmental origins of health and disease
  • Clinical epigenetics

Researcher Summary

Environmental epigenetics, DNA methylation, genome regulation, developmental origins of health and disease (DOHaD).

Subject Area: Disciplines

  • Biology: Molecular, Cellular and Whole Organism Biology: Genetics; Genomics/Bioinformatics

Research/Scholarly/Creative Works

Journal Articles
  • Broadbent JM. and Osborne AJ. (2022) Longitudinal research in Aotearoa New Zealand. Journal of the Royal Society of New Zealand 52(3): 213-215. http://dx.doi.org/10.1080/03036758.2022.2090413.
  • Noble AJ., Pearson JF., Noble AD., Boden JM., Horwood LJ., Kennedy MA. and Osborne AJ. (2022) DNA methylation analysis using bisulphite-based amplicon sequencing of individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence. Reproduction, Fertility and Development 34(7): 540-548. http://dx.doi.org/10.1071/RD21108.
  • Noble AJ., Purcell RV., Adams AT., Lam YK., Ring PM., Anderson JR. and Osborne AJ. (2022) A Final Frontier in Environment-Genome Interactions? Integrated, Multi-Omic Approaches to Predictions of Non-Communicable Disease Risk. Frontiers in Genetics 13 http://dx.doi.org/10.3389/fgene.2022.831866.
  • Noble AJ., Pearson JF., Boden JM., John Horwood L., Gemmell NJ., Kennedy MA. and Osborne AJ. (2021) A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing. PeerJ 9 http://dx.doi.org/10.7717/peerj.10762.
  • Noble A., Pearson J., Boden J., Gemmell N., Kennedy M. and Osborne A. (2020) A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing. bioRxiv http://dx.doi.org/10.1101/2020.05.25.115428.
  • Noble A., Pearson J., Noble A., Boden J., Horwood J., Kennedy M. and Osborne A. (2020) Epigenetic signatures associated with the observed link between maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence. bioRxiv http://dx.doi.org/10.1101/2020.07.02.183285.
  • Osborne AJ., Pearson JF., Noble AJ., Gemmell NJ., Horwood LJ., Boden JM., Benton MC., Macartney-Coxson DP. and Kennedy MA. (2020) Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort. Translational Psychiatry 10(1) http://dx.doi.org/10.1038/s41398-020-0800-3.
  • Stoffel MA., Humble E., Paijmans AJ., Acevedo-Whitehouse K., Chilvers BL., Dickerson B., Galimberti F., Gemmell NJ., Goldsworthy SD. and Nichols HJ. (2018) Demographic histories and genetic diversity across pinnipeds are shaped by human exploitation, ecology and life-history. Nature Communications 9(4836) http://dx.doi.org/10.1038/s41467-018-06695-z.
  • Collins CJ., Chilvers BL., Osborne A., Taylor M. and Robertson BC. (2017) Unique and isolated: population structure has implications for management of the endangered New Zealand sea lion. Conservation Genetics 18(5): 1177-1189. http://dx.doi.org/10.1007/s10592-017-0969-z.
  • Osborne AJ. and Dearden PK. (2017) A ′phenotypic hangover': the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome of Drosophila melanogaster. Environmental Epigenetics 3(4) dvx019: 19. http://dx.doi.org/10.1093/eep/dvx019.
  • Osborne AJ., Jose BR., Perry J., Smeele Z., Aitken J., Gardner PP. and Slow S. (2017) Complete genome sequences of two geographically distinct Legionella micdadei clinical isolates. American Society for Microbiology 5(e00436-17) http://dx.doi.org/10.1128/genomeA.00436-17.
  • Osborne AJ., Negro SS., Chilvers BL., Robertson BC., Kennedy MA. and Gemmell NJ. (2016) Genetic evidence of a population bottleneck and inbreeding in the endangered New Zealand sea lion Phocarctos hookeri. Journal of Heredity 107(5): 392-402. http://dx.doi.org/10.1093/jhered/esw015.
  • Osborne AJ., Pearson J., Chilvers BL., Kennedy MA. and Gemmell NJ. (2015) Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease. PLoS ONE 10(4) http://dx.doi.org/10.1371/journal.pone.0122703.
  • Osborne AJ., Pearson J., Negro SS., Louise Chilvers B., Kennedy MA. and Gemmell NJ. (2015) Heterozygote advantage at MHC DRB may influence response to infectious disease epizootics. Molecular Ecology 24(7): 1419-1432. http://dx.doi.org/10.1111/mec.13128.
  • Sadd BM., Barribeau SM., Bloch G., de Graaf DC., Dearden P., Elsik CG., Gadau J., Grimmelikhuijzen CJP., Hasselmann M. and Lozier JD. (2015) The genomes of two key bumblebee species with primitive eusocial organization. Genome Biology 16(1) 76: 31. http://dx.doi.org/10.1186/s13059-015-0623-3.
  • Osborne AJ., Zavodna M., Chilvers BL., Robertson BC., Negro SS., Kennedy MA. and Gemmell NJ. (2013) Extensive variation at MHC DRB in the New Zealand sea lion (Phocarctos hookeri) provides evidence for balancing selection. Heredity 111(1): 44-56. http://dx.doi.org/10.1038/hdy.2013.18.
  • Osborne AJ., Brauning R., Schultz JK., Kennedy MA., Slate J. and Gemmell NJ. (2011) Development of a predicted physical map of microsatellite locus positions for pinnipeds, with wider applicability to the Carnivora. Molecular Ecology Resources 11(3): 503-513. http://dx.doi.org/10.1111/j.1755-0998.2010.02962.x.
  • Schultz JK., Marshall AJ. and Pfunder M. (2010) Genome-Wide Loss of Diversity in the Critically Endangered Hawaiian Monk Seal. Diversity 2(6): 863-880. http://dx.doi.org/10.3390/d2060863.
  • Hunt GR., Abdelkrim J., Anderson MG., Holzhaider JC., Marshall AJ., Gemmell NJ. and Gray RD. (2007) Innovative pandanus-tool folding by New Caledonian crows. Australian Journal of Zoology 55(5): 291-298. http://dx.doi.org/10.1071/ZO07048.
  • Aitman TJ., Dong R., Vyse TJ., Norsworthy PJ., Johnson MD., Smith J., Mangion J., Roberton-Lowe C., Marshall AJ. and Petretto E. (2006) Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439(7078): 851-855. http://dx.doi.org/10.1038/nature04489.
  • Marshall AJ., Rattray M. and Vaughan PFT. (2006) Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative α-secretases, ADAM10 and TACE, without altering their mRNA levels. Brain Research 1099(1): 18-24. http://dx.doi.org/10.1016/j.brainres.2006.05.008.
Chapters
  • Osborne AJ., Duncan EJ., Cridge AG. and Dearden PK. (2014) Epigenetics and the Maternal Germline. In Tollefsbol T (Ed.), Transgenerational Epigenetics: 27-41.Academic Press. http://dx.doi.org/10.1016/B978-0-12-405944-3.00004-0.
Theses / Dissertations
  • Osborne AJ. (2011) Assessment of genetic variation in the threatened New Zealand sea lion, Phocarctos hookeri, and its association with fitness. University of Otago.

Review and Refereeing

  • Conservation Genetics ( 2016 - 2023)
  • Heredity ( 2015 - 2023)
  • Heredity ( 2015 - 2023)
  • Infection, Genetics and Evolution ( 2016 - 2023)
  • Journal of Heredity ( 2017 - 2023)
  • Journal of Heredity ( 2015 - 2023)
  • Journal of Heredity ( 2015 - 2023)
  • Journal of Heredity ( 2015 - 2023)
  • Marine Mammal Science ( 2016 - 2023)
  • PLoS ONE ( 2015 - 2023)
  • PLoS ONE ( 2015 - 2023)

Affiliations

  • Genetics Society of AustralAsia (GSA) (Professional Organisation): Member
  • The DOHaD Society of Australia and New Zealand (Professional Organisation): Member
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