UC Research Profile - University of Canterbury

Dr Daniel Jason Foley

Contact

Department: School of Physical & Chemical Sciences

Email: daniel.foley@canterbury.ac.nz

Direct Dial: +64 3 3690479

Office: Beatrice Tinsley 323

Language: English

About

Research / Creative works

Methods & Equipment

Fields of Research

Synthetic organic chemistry
3-D fragments
Natural product-inspired compounds
Hit development toolkits

Researcher Summary

My research is focused on the development of new synthetic methods and strategies that are intended for application in early-stage drug discovery efforts. I am especially interested in identifying enabling synthetic chemistries that can increase the versatility of fragment based-drug discovery (FBDD) programmes. Such synthetic technologies may ensure that fragments can be advanced towards higher affinity compounds (e.g. leads, drugs and chemical tools) in predictable, modular, and additive ways.

Go to this link for my personal website: https://foleynz.wixsite.com/foleylab

Subject Area: Disciplines

Chemistry: Organic Chemistry

Resources

Personal Webpages

Prizes and Awards

EPSRC Doctoral Prize Fellowship ( 2015 - 2017)

Marie Skłodowska-Curie Fellowship ( 2018 )

Max Planck Postdoctoral Fellowship ( 2017 - 2018)

Research/Scholarly/Creative Works

Journal Articles

Caplin MJ. and Foley DJ. (2021) Emergent synthetic methods for the modular advancement of sp³-rich fragments. Chemical Science 12(13): 4646-4660. http://dx.doi.org/10.1039/d1sc00161b.

Grigalunas M., Burhop A., Zinken S., Pahl A., Gally JM., Wild N., Mantel Y., Sievers S., Foley DJ. and Scheel R. (2021) Natural product fragment combination to performance-diverse pseudo-natural products. Nature Communications 12(1) http://dx.doi.org/10.1038/s41467-021-22174-4.

Karageorgis G., Foley DJ., Laraia L., Brakmann S. and Waldmann H. (2021) Pseudo Natural Products—Chemical Evolution of Natural Product Structure. Angewandte Chemie - International Edition 60(29): 15705-15723. http://dx.doi.org/10.1002/anie.202016575.

Karageorgis G., Foley DJ., Laraia L., Brakmann S. and Waldmann H. (2021) Pseudo Natural Products—Chemical Evolution of Natural Product Structure. Angewandte Chemie 133(29): 15837-15855. http://dx.doi.org/10.1002/ange.202016575.

Nöcker C., Kaiser N., Foley D., Sievers S., Janning P., Waldmann H. and Laraia L. (2021) Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones. Tetrahedron http://dx.doi.org/10.1016/j.tet.2021.132118.

Foley DJ., Zinken S., Corkery D., Laraia L., Pahl A., Wu YW. and Waldmann H. (2020) Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor. Angewandte Chemie - International Edition 59(30): 12470-12476. http://dx.doi.org/10.1002/anie.202000364.

Foley DJ., Zinken S., Corkery D., Laraia L., Pahl A., Wu YW. and Waldmann H. (2020) Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor. Angewandte Chemie 132(30): 12570-12576. http://dx.doi.org/10.1002/ange.202000364.

Karageorgis G., Foley DJ., Laraia L. and Waldmann H. (2020) Principle and design of pseudo-natural products. Nature Chemistry 12(3): 227-235. http://dx.doi.org/10.1038/s41557-019-0411-x.

Laraia L., Garivet G., Foley DJ., Kaiser N., Müller S., Zinken S., Pinkert T., Wilke J., Corkery D. and Pahl A. (2020) Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor. Angewandte Chemie - International Edition 59(14): 5721-5729. http://dx.doi.org/10.1002/anie.201913712.

Zhang R., McIntyre PJ., Collins PM., Foley DJ., Arter C., von Delft F., Bayliss R., Warriner S. and Nelson A. (2019) Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Chemistry - A European Journal 25(27): 6831-6839. http://dx.doi.org/10.1002/chem.201900815.

Aimon A., Karageorgis G., Masters J., Dow M., Craven PGE., Ohsten M., Willaume A., Morgentin R., Ruiz-Llamas N. and Lemoine H. (2018) Realisation of small molecule libraries based on frameworks distantly related to natural products. Organic and Biomolecular Chemistry 16(17): 3160-3167. http://dx.doi.org/10.1039/c8ob00688a.

Foley D. (2018) New Chemical Space for the Discovery of Bioactive Compounds. Chemistry in New Zealand 82(4): 164-164.

Robke L., Rodrigues T., Schröder P., Foley DJ., Bernardes GJL., Laraia L. and Waldmann H. (2018) Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors. Tetrahedron 74(35): 4531-4537. http://dx.doi.org/10.1016/j.tet.2018.07.021.

Foley DJ., Craven PGE., Collins PM., Doveston RG., Aimon A., Talon R., Churcher I., von Delft F., Marsden SP. and Nelson A. (2017) Synthesis and Demonstration of the Biological Relevance of sp³-rich Scaffolds Distantly Related to Natural Product Frameworks. Chemistry - A European Journal 23(60): 15227-15232. http://dx.doi.org/10.1002/chem.201704169.

Foley DJ., Nelson A. and Marsden SP. (2016) Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose? Angewandte Chemie - International Edition 55(44): 13650-13657. http://dx.doi.org/10.1002/anie.201604193.

Foley DJ., Nelson A. and Marsden SP. (2016) Evaluierung neuer Reaktionen zur Steuerung der Wirkstoff-Forschung: ein Eignungstest. Angewandte Chemie 128(44): 13850-13857. http://dx.doi.org/10.1002/ange.201604193.

Doveston RG., Tosatti P., Dow M., Foley DJ., Li HY., Campbell AJ., House D., Churcher I., Marsden SP. and Nelson A. (2015) A unified lead-oriented synthesis of over fifty molecular scaffolds. Organic and Biomolecular Chemistry 13(3): 859-865. http://dx.doi.org/10.1039/c4ob02287d.

Foley DJ., Doveston RG., Churcher I., Nelson A. and Marsden SP. (2015) A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids. Chemical Communications 51(56): 11174-11177. http://dx.doi.org/10.1039/c5cc03002a.

Castagnolo D., Foley DJ., Berber H., Luisi R. and Clayden J. (2013) Carbolithiation of S-alkenyl-N-aryl thiocarbamates: Carbanion arylation in a connective route to tertiary thiols. Organic Letters 15(9): 2116-2119. http://dx.doi.org/10.1021/ol400570r.

Conference Contributions - Published

Foley DJ., Nelson AS. and Marsden SP. (2014) Realising lead-oriented synthesis (LOS): A powerful approach to diverse, lead-like, small molecule scaffolds. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248.

Key Methodologies

Synthetic organic chemistry
Molecular property analyses