Research/Scholarly/Creative Works

• Jiao W., Fan Y., Blackmore NJ. and Parker EJ. (2020) A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis. Journal of Biological Chemistry 295(19): 6252-6262. http://dx.doi.org/10.1074/jbc.RA120.012605. (Journal Articles)

• Jiao W., Lang EJ., Bai Y., Fan Y. and Parker EJ. (2020) Diverse allosteric componentry and mechanisms control entry into aromatic metabolite biosynthesis.. Curr Opin Struct Biol 65: 159-167. http://dx.doi.org/10.1016/j.sbi.2020.06.015. (Journal Articles)

• Bai Y., Lang EJM., Nazmi AR. and Parker EJ. (2019) Domain cross-talk within a bifunctional enzyme provides catalytic and allosteric functionality in the biosynthesis of aromatic amino acids. Journal of Biological Chemistry 294(13): 4828-4842. http://dx.doi.org/10.1074/jbc.RA118.005220. (Journal Articles)

• Jiao W., Mittelstädt G., Moggré GJ. and Parker EJ. (2019) Hinge Twists and Population Shifts Deliver Regulated Catalysis for ATP-PRT in Histidine Biosynthesis. Biophysical Journal 116(10): 1887-1897. http://dx.doi.org/10.1016/j.bpj.2019.03.040. (Journal Articles)

• Van De Bittner KC., Cameron RC., Bustamante LY., Bundela R., Kessans SA., Vorster J., Nicholson MJ. and Parker EJ. (2019) Nodulisporic acid e biosynthesis:: In vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold. MedChemComm 10(7): 1160-1164. http://dx.doi.org/10.1039/c9md00143c. (Journal Articles)

• Evans GL., Furkert DP., Abermil N., Kundu P., de Lange KM., Parker EJ., Brimble MA., Baker EN. and Lott JS. (2018) Anthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha-D-ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design. Biochimica et Biophysica Acta - Proteins and Proteomics 1866(2): 264-274. http://dx.doi.org/10.1016/j.bbapap.2017.08.018. (Journal Articles)

• Fan Y., Cross PJ., Jameson GB. and Parker EJ. (2018) Exploring modular allostery via interchangeable regulatory domains. Proceedings of the National Academy of Sciences of the United States of America 115(12): 3006-3011. http://dx.doi.org/10.1073/pnas.1717621115. (Journal Articles)

• Heikal A., Nakatani Y., Jiao W., Wilson C., Rennison D., Weimar MR., Parker EJ., Brimble MA. and Cook GM. (2018) ‘Tethering’ fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase. Bioorganic and Medicinal Chemistry Letters 28(13): 2239-2243. http://dx.doi.org/10.1016/j.bmcl.2018.05.048. (Journal Articles)

• Mittelstädt G., Jiao W., Livingstone EK., Moggre GJ., Nazmi AR. and Parker EJ. (2018) A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase. Biochemical Journal 475(1): 247-260. http://dx.doi.org/10.1042/BCJ20170762. (Journal Articles)

• Nicholson MJ., Van de Bittner KC., Ram A., Bustamante LY., Scott B. and Parker EJ. (2018) Draft genome sequence of the filamentous fungus Hypoxylon pulicicidum ATCC 74245. Genome Announcements 6(2) http://dx.doi.org/10.1128/genomeA.01380-17. (Journal Articles)

• Petri J., Shimaki Y., Jiao W., Bridges HR., Russell ER., Parker EJ., Aragão D., Cook GM. and Nakatani Y. (2018) Structure of the NDH-2 – HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. Biochimica et Biophysica Acta - Bioenergetics 1859(7): 482-490. http://dx.doi.org/10.1016/j.bbabio.2018.03.014. (Journal Articles)

• Sterritt OW., Kessans SA., Jameson GB. and Parker EJ. (2018) A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux. Biochemistry 57(18): 2667-2678. http://dx.doi.org/10.1021/acs.biochem.8b00082. (Journal Articles)

• Sterritt OW., Lang EJM., Kessans SA., Ryan TM., Demeler B., Jameson GB. and Parker EJ. (2018) Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subclass. Bioscience Reports 38(5) http://dx.doi.org/10.1042/BSR20181605. (Journal Articles)

• Van De Bittner KC., Nicholson MJ., Bustamante LY., Kessans SA., Ram A., Van Dolleweerd CJ., Scott B. and Parker EJ. (2018) Heterologous Biosynthesis of Nodulisporic Acid F. Journal of the American Chemical Society 140(2): 582-585. http://dx.doi.org/10.1021/jacs.7b10909. (Journal Articles)

• Van Dolleweerd CJ., Kessans SA., Van De Bittner KC., Bustamante LY., Bundela R., Scott B., Nicholson MJ. and Parker EJ. (2018) MIDAS: A Modular DNA Assembly System for Synthetic Biology. ACS Synthetic Biology 7(4): 1018-1029. http://dx.doi.org/10.1021/acssynbio.7b00363. (Journal Articles)

• Evans GL., Furkert DP., Abermil N., Kundu P., de Lange KM., Parker EJ., Brimble MA., Baker EN. and Lott JS. (2017) Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups. Data in Brief 15: 1019-1029. http://dx.doi.org/10.1016/j.dib.2017.10.051. (Journal Articles)

• Jiao W., Blackmore NJ., Nazmi AR. and Parker EJ. (2017) Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. PLoS ONE 12(6) http://dx.doi.org/10.1371/journal.pone.0180052. (Journal Articles)

• Moggré GJ., Poulin MB., Tyler PC., Schramm VL. and Parker EJ. (2017) Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase. ACS Chemical Biology 12(10): 2662-2670. http://dx.doi.org/10.1021/acschembio.7b00484. (Journal Articles)

• Nakatani Y., Jiao W., Aragão D., Shimaki Y., Petri J., Parker EJ. and Cook GM. (2017) Crystal structure of type II NADH:quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 Å. Acta Crystallographica Section F:Structural Biology Communications 73(10): 541-549. http://dx.doi.org/10.1107/S2053230X17013073. (Journal Articles)

• Arcus VL., Prentice EJ., Hobbs JK., Mulholland AJ., Van Der Kamp MW., Pudney CR., Parker EJ. and Schipper LA. (2016) On the Temperature Dependence of Enzyme-Catalyzed Rates. Biochemistry 55(12): 1681-1688. http://dx.doi.org/10.1021/acs.biochem.5b01094. (Journal Articles)

• Arturo EC., Gupta K., Héroux A., Stith L., Cross PJ., Parker EJ., Loll PJ. and Jaffe EK. (2016) First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proceedings of the National Academy of Sciences of the United States of America 113(9): 2394-2399. http://dx.doi.org/10.1073/pnas.1516967113. (Journal Articles)

• Arturo EC., Gupta K., Heroux A., Stith L., Cross PJ., Parker EJ., Loll PJ. and Jaffe EK.. (2016) First Structure of Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of the Resting-state Tetramer. In PROTEIN SCIENCE 25: 82-83. WILEY-BLACKWELL. (Conference Contributions - Published)

• Cross PJ., Heyes LC., Zhang S., Nazmi AR. and Parker EJ. (2016) The Functional Unit of Neisseria meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric. PLoS ONE 11(2) http://dx.doi.org/10.1371/journal.pone.0145187. (Journal Articles)

• Lang EJM., Heyes LC., Jameson GB. and Parker EJ. (2016) Calculated pKa Variations Expose Dynamic Allosteric Communication Networks. Journal of the American Chemical Society 138(6): 2036-2045. http://dx.doi.org/10.1021/jacs.5b13134. (Journal Articles)

• Livingstone EK., Mittelstädt G., Given FM. and Parker EJ. (2016) Independent catalysis of the short form HisG from Lactococcus lactis. FEBS Letters : 2603-2610. http://dx.doi.org/10.1002/1873-3468.12277. (Journal Articles)

• Mittelstädt G., Moggré GJ., Panjikar S., Nazmi AR. and Parker EJ. (2016) Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail. Protein Science http://dx.doi.org/10.1002/pro.2948. (Journal Articles)

• Nazmi AR., Lang EJM., Bai Y., Allison TM., Othman MH., Panjikar S., Arcus VL. and Parker EJ. (2016) Interdomain conformational changes provide allosteric regulation en route to chorismate. Journal of Biological Chemistry 291(42): 21836-21847. http://dx.doi.org/10.1074/jbc.M116.741637. (Journal Articles)

• Reichau S., Blackmore NJ., Jiao W. and Parker EJ. (2016) Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using D-Amino Acids. PLoS ONE 11(4) http://dx.doi.org/10.1371/journal.pone.0152723. (Journal Articles)

• Blackmore NJ., Nazmi AR., Hutton RD., Webby MN., Baker EN., Jameson GB. and Parker EJ. (2015) Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: An Example of Molecular Symbiosis. The Journal of Biological Chemistry 290: 18187-18198. http://dx.doi.org/10.1074/jbc.M115.638700. (Journal Articles)

• Cookson TVM., Evans GL., Castell A., Baker EN., Lott JS. and Parker EJ. (2015) Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry 54(39): 6082-6092. http://dx.doi.org/10.1021/acs.biochem.5b00612. (Journal Articles)

• Parker EJ. (2015) The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3. Structure 23(4): 608-609. http://dx.doi.org/10.1016/j.str.2015.03.005. (Journal Articles)

• Cookson TV., Castell A., Bulloch EM., Evans GL., Short FL., Baker EN., Lott JS. and Parker EJ. (2014) Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochemical Journal 461(1): 87-98. (Journal Articles)

• Cotton T., Joseph DA. and Parker EJ. (2014) The role of sialic acid synthases in sialic acid biosynthesis. Chemistry in New Zealand 78: 69-74. (Journal Articles)

• Cotton TR., Joseph DDA., Jiao W. and Parker EJ. (2014) Probing the determinants of phosphorylated sugar-substrate binding for human sialic acid synthase. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844(12): 2257-2264. http://dx.doi.org/10.1016/j.bbapap.2014.09.014. (Journal Articles)

• Heyes LC., Reichau S., Cross PJ., Jameson GB. and Parker EJ. (2014) Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water. Bioorganic Chemistry 57: 242-250. http://dx.doi.org/10.1016/j.bioorg.2014.08.003. (Journal Articles)

• Hunter MCF. and Parker EJ. (2014) Modifying the determinants of ketoacid substrate selectivity in Mycobacterium tuberculosis isopropyl malate biosynthesis. FEBS Letters 588(9): 1603-1607. http://dx.doi.org/10.1016/j.febslet.2014.02.053. (Journal Articles)

• Joseph DA., Jiao W., Kessans SJ. and Parker EJ. (2014) Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic synthase. Proteins 82(9): 2054-2066. http://dx.doi.org/10.1002/prot.24558. (Journal Articles)

• Lang EJM., Cross PJ., Mittelstädt G., Jameson GB. and Parker EJ. (2014) Allosteric ACTion: The varied ACT domains regulating enzymes of amino-acid metabolism. Current Opinion in Structural Biology 29: 102-111. http://dx.doi.org/10.1016/j.sbi.2014.10.007. (Journal Articles)

• Naismith JH. and Parker E. (2014) Catalysis and regulation: Enzyme catalysis, biosynthetic pathways and regulation. Current Opinion in Structural Biology 29: 4-5. http://dx.doi.org/10.1016/j.sbi.2014.11.004. (Journal Articles)

• Nazmi AR., Schofield LR., Dobson RCJ., Jameson GB. and Parker EJ. (2014) Destabilization of the Homotetrameric Assembly of 3-Deoxy-d-Arabino-Heptulosonate-7-Phosphate Synthase from the Hyperthermophile Pyrococcus furiosus Enhances Enzymatic Activity. Journal of Molecular Biology 426(3): 656-673. http://dx.doi.org/10.1016/j.jmb.2013.11.008. (Journal Articles)

• Parker EJ. (2014) Enzyme regulation - twists and turns. Victoria University of Wellington, New Zealand: Centre for Biodiscovery Symposium. (Oral Presentations)

• Parker EJ. (2014) Turning enzymes on and off: Molecular communication networks. Institute of Molecular Biosciences, University of Queensland, Australia. (Oral Presentations)

• Parker EJ. (2014) Examining the allosteric properties of key metabolic enzymes. Brisbane, Australia: International Union of Pure and Applied Biophysics Conference (IUPAB), 3-7 Aug 2014. (Conference Contributions - Other)

• Parker EJ. (2014) Examining, engineering and evolving enzyme regulation. Queenstown, New Zealand: Queenstown Molecular Biology Drug Discovery and Development Satellite (QMB), 31 Aug-4 Sep 2014. (Conference Contributions - Other)

• Parker EJ. (2014) Turning enzymes on and off: Divergent protein allostery. Manchester, UK: Enzyme Mechanisms of Biological Systems Conference (EMBO), 1-4 Jun 2014. (Conference Contributions - Other)

• Allison TM., Cochrane FC., Jameson GB. and Parker EJ. (2013) Examining the role of intersubunit contacts in catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Biochemistry 52(27): 4676-4686. http://dx.doi.org/10.1021/bi400521f. (Journal Articles)

• Blackmore NJ., Reichau S., Jiao W., Hutton RD., Baker EN., Jameson GB. and Parker EJ. (2013) Three Sites and You Are Out: Ternary Synergistic Allostery Controls Aromatic Amino Acid Biosynthesis in Mycobacteriumtuberculosis. Journal of Molecular Biology 425(9): 1582-1592. http://dx.doi.org/10.1016/j.jmb.2012.12.019. (Journal Articles)

• Castell A., Short FL., Evans GL., Cookson TVM., Bulloch EMM., Joseph DDA., Lee CE., Parker EJ., Baker EN. and Lott JS. (2013) Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry 52(10): 1776-1787. http://dx.doi.org/10.1021/bi301387m. (Journal Articles)

• Cross PJ. and Parker EJ. (2013) Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino heptulosonate 7-phosphate synthase. FEBS letters 587(18): 3063-3068. http://dx.doi.org/10.1016/j.febslet.2013.07.044. (Journal Articles)

• Cross PJ., Allison TM., Dobson RCJ., Jameson GB. and Parker EJ. (2013) Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain. Proceedings of the National Academy of Sciences of the United States of America 110(6): 2111-2116. http://dx.doi.org/10.1073/pnas.1217923110. (Journal Articles)

• Cross PJ., Pietersma AL., Allison TM., Wilson-Coutts SM., Cochrane FC. and Parker EJ. (2013) Neisseria meningitidis expresses a single 3-deoxy-D-arabino heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine. Protein Science 22: 1087-1099. http://dx.doi.org/10.1002/pro.2293. (Journal Articles)

• Hobbs JK., Jiao W., Easter AD., Parker EJ., Schipper LA. and Arcus VA. (2013) Change in Heat capacity for enzyme catalysis determines temperature dependence of enzyme catalysed rates. ACS Chemical Biology 8(11): 2388-2393. http://dx.doi.org/10.1021/cb4005029. (Journal Articles)

• Huisman FHA., Squire CJ. and Parker EJ. (2013) Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications 433(2): 249-254. http://dx.doi.org/10.1016/j.bbrc.2013.02.092. (Journal Articles)

• Joseph DD., Jiao W. and Parker EJ. (2013) Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis. Biochemistry http://dx.doi.org/10.1021/bi400062c. (Journal Articles)

• Mittelstadt G., Negron L., Schofield LR., Marsh K. and Parker EJ. (2013) Biochemical and structural characterisation of dehydroquinate synthase from the New Zealand kiwifruit Actinidia chinensis. Archives of Biochemistry and Biophysics 537(2): 185-191. http://dx.doi.org/10.1016/j.abb.2013.07.022. (Journal Articles)

• Reichau S. and Parker EJ. (2013) Active site plasticity of a critical enzyme from Mycobacterium tuberculosis. RSC Advances 3: 3209-3212. http://dx.doi.org/10.1039/c3ra00037k. (Journal Articles)

• Scott B., Young CA., Saikia S., McMillan LK., Monahan BJ., Koulman A., Astin J., Eaton CJ., Bryant A. and Wreen RE. (2013) Deletion and Gene Expression Analyses Define the Paxilline Biosynthetic Gene Cluster in Penicillium paxilli. Toxins 5(8): 1422-1446. http://dx.doi.org/10.3390/toxins5081422. (Journal Articles)

• Xiong X., Xu Z., Yang Z., Liu Y., Wang D., Dong M., Parker EJ. and Zhu W. (2013) Key Targets and Relevant Inhibitors for the Drug Discovery of Tuberculosis. Current Drug Targets 14(6): 676-699. (Journal Articles)

• Harrison AN., Reichau S. and Parker EJ. (2012) Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Bioorganic & Medicinal Chemistry Letters 22(2): 907-911. http://dx.doi.org/10.1016/j.bmcl.2011.12.025. (Journal Articles)

• Huisman FHA., Koon N., Bulloch EMM., Baker HM., Baker EN., Squire CJ. and Parker EJ. (2012) Removal of the C-Terminal Regulatory Domain of α-Isopropylmalate Synthase Disrupts Functional Substrate Binding. Biochemistry 51(11): 2289-2297. http://dx.doi.org/10.1021/bi201717j. (Journal Articles)

• Jiao W. and Parker EJ. (2012) Using a Combination of Computational and Experimental Techniques to Understand the Molecular Basis for Protein Allostery. In Christov C; Karabencheva T (Ed.), Advances in Protein Chemistry and Structural Biology Vol 87: Structural and Mechanistic Enzymology - Bringing Together Experiments and Computing: 391-413. Oxford: Elsevier. http://dx.doi.org/10.1016/B978-0-12-398312-1.00013-5. (Chapters)

• Jiao W., Hutton RD., Cross PJ., Jameson GB. and Parker EJ. (2012) Dynamic cross-talk among remote binding sites: The molecular basis for unusual synergistic allostery. Journal of Molecular Biology 415(4): 716-726. http://dx.doi.org/10.1016/j.jmb.2011.11.037. (Journal Articles)

• Allison TM., Hutton RD., Cochrane FC., Yeoman JA., Jameson GB. and Parker EJ. (2011) Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Biochemistry 50(18): 3686-3695. http://dx.doi.org/10.1021/bi200251f. (Journal Articles)

• Allison TM., Hutton RD., Jiao W., Gloyne BJ., Nimmo EB., Jameson GB. and Parker EJ. (2011) An extended β7α7 substrate-binding loop is essential for efficient catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Biochemistry 50(43): 9318-9327. http://dx.doi.org/10.1021/bi201231e. (Journal Articles)

• Cross PJ., Dobson RCJ., Patchett ML. and Parker EJ. (2011) Tyrosine Latching of a Regulatory Gate Affords Allosteric Control of Aromatic Amino Acid Biosynthesis. The Journal of Biological Chemistry 286(12): 10216-10224. http://dx.doi.org/10.1074/jbc.M110.209924. (Journal Articles)

• Negron L. and Parker EJ. (2011) Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase. Organic & Biomolecular Chemistry 9(8): 2861-2867. http://dx.doi.org/10.1039/C0OB01141J. (Journal Articles)

• Negron L., Patchett ML. and Parker EJ. (2011) Expression, Purification, and Characterisation of Dehydroquinate Synthase from Pyrococcus furiosus. Enzyme Research 2011: 134893. http://dx.doi.org/10.4061/2011/134893. (Journal Articles)

• Parker EJ. (2011) Allosteric regulation of the shikimate pathway. Waterville Valley, New Hampshire, USA: Gordon Research Conference: Enzymes, Coenzymes & Metabolic Pathways, 10-15 Jul 2011. (Conference Contributions - Other)

• Parker EJ. (2011) Diverging Mechanisms for the inhibition of a Crucial Biosynthetic Aldolase. Rotorua, New Zealand: Crystal 27 SCANZ Conference, 27-30 Apr 2011. (Conference Contributions - Other)

• Parker EJ. (2011) Enzyme Dynamics and Allosteric Signal Transduction: Examining the Large- and Small-Scale Protein Motions. Hamilton, New Zealand: New Zealand Institute of Chemistry Conference, 27 Nov-1 Dec 2011. (Conference Contributions - Other)

• Parker EJ. and Pratt AJ. (2011) Amino Acid Biosynthesis. In Hughes AB (Ed.), Building Blocks, Catalysis and Coupling Chemistry. Amino Acids, Peptides and Proteins in Organic Chemistry Vol 3: 1-82. Weinheim: Wiley-VCH. http://dx.doi.org/10.1002/9783527631803.ch1. (Chapters)

• Reichau S., Jiao WT., Walker SR., Hutton RD., Baker EN. and Parker EJ. (2011) Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: Combining mechanism- and modeling-based design. Journal of Biological Chemistry 286(18): 16197-16207. http://dx.doi.org/10.1074/jbc.M110.211649. (Journal Articles)

• Tran D., Pietersma AL., Schofield LR., Rost M., Jameson GB. and Parker EJ. (2011) Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway. Bioorganic & Medicinal Chemistry Letters 21(22): 6838-6841. http://dx.doi.org/10.1016/j.bmcl.2011.09.017. (Journal Articles)

• Walker SR., Jiao W. and Parker EJ. (2011) Synthesis and evaluation of dual site inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase. Bioorganic & Medicinal Chemistry Letters 21(17): 5092-5097. http://dx.doi.org/10.1016/j.bmcl.2011.03.071. (Journal Articles)

• Allison TM., Yeoman JA., Hutton RD., Cochrane FC., Jameson GB. and Parker EJ. (2010) Specificity and mutational analysis of the metal-dependent 3-deoxy-D-manno-octulosonate 8-phosphate synthase from Acidithiobacillus ferrooxidans. Biochimica Et Biophysica Acta (BBA) - Proteins & Proteomics 1804(7): 1526-1536. http://dx.doi.org/10.1016/j.bbapap.2010.04.005. (Journal Articles)

• Huisman FHA., Hunter MFC., Devenish SRA., Gerrard JA. and Parker EJ. (2010) The C-terminal regulatory domain is required for catalysis by Neisseria meningitidis α-isopropylmalate synthase. Biochemical and Biophysical Research Communications 393(1): 168-173. http://dx.doi.org/10.1016/j.bbrc.2010.01.114. (Journal Articles)

• Jiao WT., McDonald Q., Coxon JM. and Parker EJ. (2010) Molecular Modeling Studies of Peptide Inhibitors Highlight the Importance of Conformational Prearrangement for Inhibition of Calpain. Biochemistry 49(26): 5533-5539. http://dx.doi.org/10.1021/bi100048y. (Journal Articles)

• Parker EJ. (2010) Essential TB enzymes as drug targets. Auckland, New Zealand: New Zealand 'Superbugs' Symposium, 16-16 Nov 2010. (Conference Contributions - Other)

• Parker EJ. (2010) Exploring the evolutionary relationships and the reaction chemistry in a family of crucial biosynthetic aldolases. St Andrews, UK: Royal Society of Chemistry Prizes and Awards Symposium, 28-28 Apr 2010. (Conference Contributions - Other)

• Parker EJ. (2010) Natural and synthetic inhibitors of key biosynthetic aldolases. Melbourne, Australia: Royal Australian Chemical Institute (RACI) Convention, 4-8 Jul 2010. (Conference Contributions - Other)

• Parker EJ. (2010) Natural and synthetic inhibitors of key biosynthetic aldolases. Queenstown, New Zealand: Queenstown Molecular Biology Drug Discovery and Development Satellite (QMB), 2-3 Sep 2010. (Conference Contributions - Other)

• Parker EJ. (2010) Probing the mechanistic subtleties of a family of crucial biosynthetic aldolases. Honolulu, HI, USA: Pacifichem 2010, 15-20 Dec 2010. (Conference Contributions - Other)

• Webby CJ., Jiao W., Hutton RD., Blackmore NJ., Baker HM., Baker EN., Jameson GB. and Parker EJ. (2010) Synergistic Allostery, a Sophisticated Regulatory Network for the Control of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis. Journal of Biological Chemistry 285(40): 30567-30576. http://dx.doi.org/10.1074/jbc.M110.111856. (Journal Articles)

• Cochrane FC., Cookson TVM., Jameson GB. and Parker EJ. (2009) Erratum to "Reversing Evolution: Re-establishing Obligate Metal Ion Dependence in a Metal-independent KDO8P Synthase" [J. Mol. Biol. 390 (2009) 646-661] (DOI:10.1016/j.jmb.2009.05.014). Journal of Molecular Biology 393(4): 1004-1005. http://dx.doi.org/10.1016/j.jmb.2009.07.058. (Journal Articles)

• Cochrane FC., Cookson TVM., Jameson GB. and Parker EJ. (2009) Reversing Evolution: Re-establishing Obligate Metal Ion Dependence in a Metal-independent KDO8P Synthase. Journal of Molecular Biology 390(4): 646-661. http://dx.doi.org/10.1016/j.jmb.2009.05.014. (Journal Articles)

• Devenish SRA., Huisman FHA., Parker EJ., Hadfield AT. and Gerrard JA. (2009) Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1794: 1168-1174. http://dx.doi.org/10.1016/j.bbapap.2009.02.003. (Journal Articles)

• Walker SR., Cumming H. and Parker EJ. (2009) Substrate and reaction intermediate mimics as inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Organic & Biomolecular Chemistry 7: 3031-3035. http://dx.doi.org/10.1039/b909241b. (Journal Articles)

• Ahn M., Cochrane FC., Patchett ML. and Parker EJ. (2008) Arabinose 5-phosphate analogues as mechanistic probes for Neisseria meningitidis 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Bioorganic & Medicinal Chemistry 16(22): 9830-9836. http://dx.doi.org/10.1016/j.bmc.2008.09.056. (Journal Articles)

• Parker E. (2008) Reversing evolution: re-establishing obligate metal-ion dependency in a metal-independent KDO8P synthase. Queenstown, New Zealand: The 18th Queenstown Molecular Biology Meetings, 31 Aug-6 Sep 2008. (Conference Contributions - Other)

• Parker EJ. (2008) Evolving enzymes: Deciphering the evolutionary relationships in a family of crucial biosynthetic aldolases. Australian National University, Australia: Invited seminar, 20 Oct 2008. (Oral Presentations)

• Parker EJ. (2008) Design, synthesis and evaluation of inhibitors of two key biosynthetic enzymes. Dunedin, New Zealand: Chemistry and the Biosphere Conference, 30 Nov-4 Dec 2008. (Conference Contributions - Other)

• Parker EJ. (2008) Evolving enzymes: Deciphering the evolutionary relationships in a family of crucial biosynthetic aldolases. Dunedin, New Zealand: Chemistry and the Biosphere Conference, 30 Nov-4 Dec 2008. (Conference Contributions - Other)

• Parker EJ. (2008) Re-establishing a metal-binding scaffold in a metal-independent KDO8P synthase. Lorne, Australia: 33rd Lorne Conference on Protein Structure and Function, 10-14 Feb 2008. (Conference Contributions - Other)

• Saikia S., Nicholson MJ., Young C., Parker EJ. and Scott B. (2008) The genetic basis for indole-diterpene chemical diversity in filamentous fungi. Mycological Research 112(2): 184-199. http://dx.doi.org/10.1016/j.mycres.2007.06.015. (Journal Articles)

• Parker EJ. (2007) Mechanistic divergence and inhibition of a family of crucial biosynthetic enzymes. Adelaide, Australia: 22nd Royal Australian Chemical Institute Organic Conference (22RACIOC), 28 Jan-2 Feb 2007. (Conference Contributions - Other)

• Parker EJ., Webby CJ., Pietersma AL., Ahn M., Cochrane FC., Jameson GB. and Schofield R. (2007) Evolving enzymes: Exploring the interplay of sequence structure and reaction chemistry. Lorne, Australia: 32nd Lorne Conference on Protein Structure and Function, 4-8 Feb 2007. (Conference Contributions - Other)

• Saikia S., Parker EJ., Koulman A. and Scott B. (2007) Defining Paxilline Biosynthesis in Penicillium paxilli - Functional characterization of two cytochrome p450 monooxygenases. Journal of Biological Chemistry 282(23): 16829-16837. http://dx.doi.org/10.1074/jbc.M701626200. (Journal Articles)

• Scott B., Young CA., Tanaka A. and Parker EJ. (2007) Molecular and genetic analysis of symbiosis expressed secondary metabolite genes from the mutualistic fungal endophytes Neotyphodium lolii and Epichloë festucae. In Robson GD; Van West P; Gadd GM (Ed.), British Mycological Society Symposia Vol 26: Exploitation of Fungi: 59-77. Cambridge: Cambridge University Press. (Chapters)

• Walter., M., Ford., I C., Guthrie., M J., Boyd-Wilson., H KS., Di. and J H. (2007) Bioremediation of Aged Pentachlorophenol Residues by Trametes spp. In Rai M (Ed.), Mycotechnology: Present Status and Future Prospects: 18-54. New Delhi: I.K. International. (Chapters)

• Bryan GT., Johnson RD., Parker EJ., Scott DB. and Tanaka A. (2006) Peramine Biosynthesis.Patent No. 540677. (Intellectual Property)

• Cochrane FC., Patchett ML., Jameson GB. and Parker EJ. (2006) Re-establishing a metal-binding scaffold in a metal-independent KDO8P synthase. Rotorua, New Zealand: NZIC Conference 2006 "Back to the Basics: From Small Molecules to Materials and Surfaces", 2-6 Dec 2006. (Conference Contributions - Other)

• Cumming H. and Parker EJ. (2006) Substrate Analogues to Probe the Mechanisms of two Bacterial Enzymes. Rotorua, New Zealand: NZIC Conference 2006 "Back to the Basics: From Small Molecules to Materials and Surfaces", 2-6 Dec 2006. (Conference Contributions - Other)

• Harrison AN. and Parker EJ. (2006) Inhibitor Analogue Studies on KDO8P Synthase. Rotorua, New Zealand: NZIC Conference 2006 "Back to the Basics: From Small Molecules to Materials and Surfaces", 2-6 Dec 2006. (Conference Contributions - Other)

• Parker EJ. (2006) Evolving enzymes: Exploring the interplay of sequence, structure and reaction chemistry in a family of crucial biosynthetic enzymes. School of Biological Sciences, University of Canterbury, Christchurch, New Zealand: 12 May 2006. (Oral Presentations)

• Parker EJ. (2006) Evolving Chemistry: Mechanistic and regulatory divergence in a family of crucial biosynthetic enzymes. Rotorua, New Zealand: NZIC Conference 2006 "Back to the Basics: From Small Molecules to Materials and Surfaces", 2-6 Dec 2006. (Conference Contributions - Other)

• Saikia S., Parker EJ., Koulman A. and Scott B. (2006) Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline. FEBS Letters 580(6): 1625-1630. http://dx.doi.org/10.1016/j.febslet.2006.02.008. (Journal Articles)

• Walker SR. and Parker EJ. (2006) Design and Synthesis of inhibitors of the DAH7P synthase reaction. Rotorua, New Zealand: NZIC Conference 2006 "Back to the Basics: From Small Molecules to Materials and Surfaces", 2-6 Dec 2006. (Conference Contributions - Other)

• Walker SR. and Parker EJ. (2006) Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase. Bioorganic & Medicinal Chemistry Letters 16(11): 2951-2954. http://dx.doi.org/10.1016/j.bmcl.2006.02.073. (Journal Articles)

• Ahn M., Pietersma AL., Schofield LR. and Parker EJ. (2005) Mechanistic divergence of two closely related aldol-like enzyme-catalysed reactions. Organic and Biomolecular Chemistry 3: 4046-4049. (Journal Articles)

• Anderson BF., Norris GE., Schofield LR., Patchett ML., Jameson GB. and Parker EJ. (2005) Crystal structures of DAH7PS synthase from Pyrococccus furiosus. Florence, Italy: XX Congress of the International Union of Crystallography, 23 Aug 2005. (Conference Contributions - Other)

• Bryan G., Johnson RD., Parker EJ., Scott BB. and Tanaka A. (2005) Peramine biosynthesis [Examination].Patent No. 540677. (Intellectual Property)

• Parker EJ. and Scott BB. (2005) Indole-diterpene biosynthesis in ascomycetous fungi. In An Z (Ed.), Handbook of Industrial Mycology: 405-426. New York: Marcel Dekker. (Chapters)

• Schofield LR., Anderson BF., Patchett ML., Norris GE., Jameson GB. and Parker EJ. (2005) Structure and function of Pyrococcus furiosus DAH7P synthase: The ancestral type I enzyme. Honolulu, HI, USA: Pacifichem, 15 Dec 2005. (Conference Contributions - Other)

• Schofield LR., Anderson BF., Patchett ML., Norris GE., Jameson GB. and Parker EJ. (2005) Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D arabino-heptulosonate -7- phosphate synthase: An ancestral 3-deoxyald-2-ulosonate-phosphate synthase? Biochemistry 44: 11950-11962. (Journal Articles)

• Tanaka A., Tapper B., Popay A., Parker EJ. and Scott B. (2005) A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory. Molecular Microbiology 57: 1036-1050. (Journal Articles)

• Webby CJ., Baker HM., Lott JS., Baker EN. and Parker EJ. (2005) The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. Journal of Molecular Biology 354: 927-939. (Journal Articles)

• Webby CJ., Lott JS., Baker HM., Baker EN. and Parker EJ. (2005) Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61: 403-406. (Journal Articles)

• Webby CJ., Patchett ML. and Parker EJ. (2005) Characterization of a recombinant type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Helicobacter pylori. Biochemical Journal 390: 223-230. (Journal Articles)

• Williamson RM., Pietersma AL., Jameson GB. and Parker EJ. (2005) Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Bioorganic and Medicinal Chemistry Letters 15: 2339-2342. (Journal Articles)

• Bulloch EMM., Jones MA., Parker EJ., Osborne AP., Stephens E., Davies GM., Coggins JR. and Abell C. (2004) Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6S)-6-fluoroshikimate. Journal of the American Chemical Society 126(32): 9912-9913. (Journal Articles)

• Schofield LR., Patchett ML. and Parker EJ. (2004) Expression, purification, and characterization of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Pyrococcus furiosus. Protein Expression & Purification 34(1): 17-27. (Journal Articles)

• Schofield LR., Patchett ML. and Parker EJ. (2004) Studies of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Pyrococcus furiosus. Lorne, Australia: 29th Annual Lorne Conference on Protein Structure and Function, 8 Feb 2004. (Conference Contributions - Other)

• Scott BB., Jameson GB. and Parker EJ. (2004) Isoprenoids: Gene clusters and chemical puzzles. In Tkacz JS; Lange L (Ed.), Advances in Fungal Biotechnology for Industry, Agriculture, and Medicine: 163-198. New York: Kluwer Academic/Plenum Publishers. (Chapters)

• Webby CJ., Patchett ML. and Parker EJ. (2004) Solubilization, purification and characterization of type II DAH7P synthases from H. pylori and M. tuberculosis. Queenstown, New Zealand: 14th Annual Queenstown Molecular Biology Meeting, 28 Nov 2004. (Conference Contributions - Other)

• Webby CJ., Patchett ML. and Parker EJ. (2004) Structural and mechanistic comparison of class I and class II 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) synthases. Lorne, Australia: 29th Annual Lorne Conference on Protein Structure and Function, 8 Feb 2004. (Conference Contributions - Other)

• Bryan JT., Johnson R., Scott BB., Young CA., Parker E. and Tapper BA. (2003) Indole-diterpene biosynthesis [Examination].Patent No. 530331. (Intellectual Property)

• Frederickson M., Parker EJ., Coggins JR. and Abell C. (2003) Enzymic synthesis of 3-[3-13C]dehydroquinic acid. Organic & Biomolecular Chemistry 1(19): 3271-3273. (Journal Articles)

• McMillan LK., Carr RL., Young CA., Astin JW., Lowe RGT., Parker EJ., Jameson GB., Finch SC., Miles CO. and McManus OB. (2003) Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels. Molecular Genetics and Genomics 270(1): 9-23. (Journal Articles)

• Schofield LR., Patchett ML. and Parker EJ. (2003) Probing the mechanism of the first enzyme of the Shikimate pathway. Nelson, New Zealand: The 2003 New Zealand Institute of Chemistry Conference, 30 Nov 2003. (Conference Contributions - Other)

• Walter M., Guthrie JM., Sivakumaran S., Parker E., Slade A., McNaughton D. and Boyd-Wilson KSH. (2003) Screening of New Zealand native white-rot isolates for PCP degradation. Bioremediation Journal 7(2): 119-128. http://dx.doi.org/10.1080/713607977. (Journal Articles)

• Walter M., Guthrie JM., Sivakumaran S., Parker EJ., Slade A., McNaughton D. and Boyd-Wilson KSH. (2003) Screening of New Zealand native white-rot isolates for PCP degradation. Bioremediation Journal 7(2): 119-128. (Journal Articles)

• Mathews CM., Norris GE., Patchett ML. and Jameson GB. (2002) Substrate deactivation of a key biosynthetic enzyme. Lorne, Australia: 27th Annual Conference on Protein Structure and Function, 10 Feb 2002. (Conference Contributions - Other)

• Parker EJ., Bulloch EMM., Jameson GB. and Abell C. (2001) Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate. Biochemistry 40(49): 14821-14828. (Journal Articles)

• Frederickson M., Parker EJ., Hawkins AR., Coggins JR. and Abell C. (2000) Selective Inhibition of Type II Dehydroquinases. Journal of Organic Chemistry 64(8): 2612-2613. (Journal Articles)

• Parker EJ., Bello CG., Coggins JR., Hawkins AR. and Abell C. (2000) Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids. Bioorganic & Medicinal Chemistry Letters 10(3): 231-234. (Journal Articles)

• Osborne AP., Parker EJ. and Abell C. (1999) Biotransformations to generate fluorinated analogues of shikimate pathway intermediates. Fluorinated Bioact Compd Agric Med Fields : 10pp. (Journal Articles)

• Parker EJ., Coggins JR. and Abell C. (1997) Derailing dehydroquinate synthase by introducing a stabilising stereoelectronic effect in a reaction intermediate. Journal of Organic Chemistry 62: 8582-8585. (Journal Articles)

• Duggan PJ., Parker E., Coggins J. and Abell C. (1995) ENZYMATIC SYNTHESIS OF (6R) AND (6S)-FLUOROSHIKIMIC ACIDS. Bioorganic and medicinal chemistry letters 5(20): 2347-2352. (Journal Articles)

• Abell AD., Hoult DA. and Jamieson EJ. (1992) Synthesis of 1,2-disubstituted pyrroles: a cis peptide bond surrogate. Tetrahedron Letters 33: 5831-5832. (Journal Articles)

Editorial Work

• Lecture Notes in Chemistry Series Editor ( 2010 - 2020)

Review and Refereeing

• Acta Crystallographica ( 2006 - 2020)
• Acta Crystallographica ( 2000 - 2020)
• Acta Crystallographica ( 2000 - 2005)
• Bioorganic and Medicinal Chemistry ( 2000 - 2020)
• Bioorganic and Medicinal Chemistry ( 2000 - 2005)
• Bioorganic and Medicinal Chemistry ( 2006 - 2020)
• Bioorganic and Medicinal Chemistry Letters ( 2006 - 2020)
• Bioorganic and Medicinal Chemistry Letters ( 2000 - 2020)
• ChemBioChem ( 2006 - 2020)
• ChemMedChem ( 2006 - 2020)
• Journal of Biological Chemistry ( 2006 - 2020)
• Journal of Chemical Education ( 2006 - 2020)
• Journal of Chemical Education ( 2006 - 2020)
• Journal of Chemical Education ( 2000 - 2020)
• Journal of Inorganic Biochemistry ( 2006 - 2020)
• Organic and Biomolecular Chemistry ( 2006 - 2020)
• Organic and Molecular Chemistry ( 2006 - 2020)
• Plant Physiology ( 2006 - 2020)
• Plant Physiology ( 2000 - 2020)
• Plant Physiology ( 2000 - 2005)
• PLoS Computational Biology ( 2006 - 2020)
• PLoS ONE ( 2006 - 2020)