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Dr Sarah Kessans

Contact

Department: School of Product Design

Email: sarah.kessans@canterbury.ac.nz

Direct Dial: +64 3 3692140

Office: West 325

Language: English

Developing synthetic biology solutions to combat climate change, facilitate space habitation, and advance innovations in medicine and agriculture.
About
Research / Creative works

Researcher Summary

Developing synthetic biology solutions to combat climate change, facilitate space habitation, and advance innovations in medicine and agriculture.

Subject Area: Disciplines

  • Chemistry: Enzymology; Natural Products
  • Engineering and Technology: Bioengineering
  • Biology: Molecular, Cellular and Whole Organism Biology: Biochemistry; Molecular Biology

Resources

  • LinkedIn

Research/Scholarly/Creative Works

  • Kessans S., Parker EJ. and Nicholson MJ. (2020) Delivering methane inhibitors to pasture-fed ruminants. Wellington, New Zealand: Ministry for Primary Industries and Global Research Alliance on Agricultural Greenhouse Gases Annual Science Presentations, 4-6 Aug 2020. (Conference Contributions - Other)
  • Kessans S., Parker EJ. and Nicholson MJ. (2020) Delivering methane inhibitors to pasture-fed ruminants. In Delivering methane inhibitors to pasture-fed ruminants final report, Commissioned by New Zealand Agricultural Greenhouse Gas Research Centre. (Reports)
  • Kessans SA., Nicholson MJ., Parker EJ., Rodriguez LYB., Scott DB., Van de Bittner KC., van Dolleweerd CJ. and Kessans S. (2020) Heterologous biosynthesis of nodulisporic acid.Patent No. 2020/0299700 A1, USA. (Intellectual Property)
  • Meador LR., Kessans SA., Kilbourne J., Kibler KV., Pantaleo G., Esteban M., Blattman JN., Jacobs BL. and Mor TS. (2019) Corrigendum to “A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles” (Virology (2017) 507 (242–256), (S0042682217301095), (10.1016/j.virol.2017.04.008)). Virology 534: 143. http://dx.doi.org/10.1016/j.virol.2019.05.018. (Journal Articles)
  • Van De Bittner KC., Cameron RC., Bustamante LY., Bundela R., Kessans SA., Vorster J., Nicholson MJ. and Parker EJ. (2019) Nodulisporic acid e biosynthesis:: In vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold. MedChemComm 10(7): 1160-1164. http://dx.doi.org/10.1039/c9md00143c. (Journal Articles)
  • North RA., Wahlgren WY., Remus DM., Scalise M., Kessans SA., Dunevall E., Claesson E., da Costa TPS., Perugini MA. and Ramaswamy S. (2018) The Sodium Sialic acid symporter from Staphylococcus aureus has altered substrate specificity. Frontiers in Chemistry 6(JUL) http://dx.doi.org/10.3389/fchem.2018.00233. (Journal Articles)
  • Sterritt OW., Kessans SA., Jameson GB. and Parker EJ. (2018) A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux. Biochemistry 57(18): 2667-2678. http://dx.doi.org/10.1021/acs.biochem.8b00082. (Journal Articles)
  • Sterritt OW., Lang EJM., Kessans SA., Ryan TM., Demeler B., Jameson GB. and Parker EJ. (2018) Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subclass. Bioscience Reports 38(5) http://dx.doi.org/10.1042/BSR20181605. (Journal Articles)
  • Van De Bittner KC., Nicholson MJ., Bustamante LY., Kessans SA., Ram A., Van Dolleweerd CJ., Scott B. and Parker EJ. (2018) Heterologous Biosynthesis of Nodulisporic Acid F. Journal of the American Chemical Society 140(2): 582-585. http://dx.doi.org/10.1021/jacs.7b10909. (Journal Articles)
  • Van Dolleweerd CJ., Kessans SA., Van De Bittner KC., Bustamante LY., Bundela R., Scott B., Nicholson MJ. and Parker EJ. (2018) MIDAS: A Modular DNA Assembly System for Synthetic Biology. ACS Synthetic Biology 7(4): 1018-1029. http://dx.doi.org/10.1021/acssynbio.7b00363. (Journal Articles)
  • Bustamante L., Kessans S., Nicholson M., Parker E., Scott B., van de Bittner K. and van Dolleweerd C. (2017) Heterologous Biosynthesis of Nodulisporic Acid.Patent No. AU2017903956. (Intellectual Property)
  • Meador LR., Kessans SA., Kilbourne J., Kibler KV., Pantaleo G., Roderiguez ME., Blattman JN., Jacobs BL. and Mor TS. (2017) A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles. Virology 507: 242-256. http://dx.doi.org/10.1016/j.virol.2017.04.008. (Journal Articles)
  • Nicholson M., Parker E. and van Dolleweerd C. (2017) Modular DNA Assembly System.Patent No. AU2017903955. (Intellectual Property)
  • Donovan KA., Atkinson SA., Kessans SA., Peng F., Cooper TF., Griffin MDW., Jameson GB. and Dobson RCJ. (2016) Grappling with anisotropic data, pseudo-merohedral twinning and pseudo-translational non-crystallographic symmetry: A case study involving pyruvate kinase. Acta Crystallographica Section D: Structural Biology 2016(D72): 512-519. http://dx.doi.org/10.1107/S205979831600142X. (Journal Articles)
  • Donovan KA., Zhu S., Liuni P., Peng F., Kessans SA., Wilson DJ. and Dobson RCJ. (2016) Conformational Dynamics and Allostery in Pyruvate Kinase. Journal of Biological Chemistry 291(17): 9244-9256. http://dx.doi.org/10.1074/jbc.M115.676270. (Journal Articles)
  • Kessans SA., Linhart MD., Meador LR., Kilbourne J., Hogue BG., Fromme P., Matoba N. and Mor TS. (2016) Immunological Characterization of Plant-Based HIV-1 Gag/Dgp41 Virus-Like Particles. PLoS ONE 11(3) e0151842 http://dx.doi.org/10.1371/journal.pone.0151842. (Journal Articles)
  • Chen K., Hu J., Moore DL., Liu R., Breslin K., Jansz N., Kessans SA., Lucet IS., Keniry A. and Leong HS. (2015) SCREENING FOR AND CHARACTERISING MAMMALIAN EPIGENETIC MODIFIERS. In JOURNAL OF GENE MEDICINE 17(8-9): 181-182. WILEY-BLACKWELL. (Conference Contributions - Published)
  • Chen K., Hu J., Moore DL., Liu R., Kessans SA., Breslin K., Lucet IS., Keniry A., Leong HS. and Parish CL. (2015) Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation. Proceedings of the National Academy of Sciences of the United States of America 112(27): E3535-E3544. http://dx.doi.org/10.1073/pnas.1504232112. (Journal Articles)
  • Mason HS., Thuenemann E., Kiyono H., Kessans S., Matoba N. and Mor T. (2015) Mucosal Vaccines from Plant Biotechnology. Mucosal Immunology: Fourth Edition: 1271-1289. http://dx.doi.org/10.1016/B978-0-12-415847-4.00065-3. (Chapters)
  • Crowther JM., Lassé M., Suzuki H., Kessans SA., Loo TS., Norris GE., Hodgkinson AJ., Jameson GB. and Dobson RCJ. (2014) Ultra-high resolution crystal structure of recombinant caprine β-lactoglobulin. FEBS Letters 588(21): 3816-3822. http://dx.doi.org/10.1016/j.febslet.2014.09.010. (Journal Articles)
  • Gong Z., Kessans SA., Song L., Dörner K., Lee HH., Meador LR., Labaer J., Hogue BG., Mor TS. and Fromme P. (2014) Recombinant expression, purification, and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41. Protein Science 23(11): 1607-1618. http://dx.doi.org/10.1002/pro.2540. (Journal Articles)
  • Joseph DA., Jiao W., Kessans SJ. and Parker EJ. (2014) Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic synthase. Proteins 82(9): 2054-2066. http://dx.doi.org/10.1002/prot.24558. (Journal Articles)
  • North RA., Kessans SA., Griffin MDW., Watson AJA., Fairbanks AJ. and Dobson RCJ. (2014) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistant Staphylococcus aureus. Acta Crystallographica Section F: Structural Biology Communications 70(5): 650-655. http://dx.doi.org/10.1107/S2053230X14007171. (Journal Articles)
  • North RA., Kessans SA., Suzuki H., Griffin MD. and Dobson RC. (2014) Probing Novel Antibiotic Targets Within Sialic Acid Catabolism. In PROTEIN SCIENCE 23: 168-168. WILEY-BLACKWELL. (Conference Contributions - Published)
  • North RA., Seizova S., Stampfli A., Kessans SA., Suzuki H., Griffin MDW., Kvansakul M. and Dobson RCJ. (2014) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus aureus. Acta Crystallographica Section F: Structural Biology Communications 70(5): 643-649. http://dx.doi.org/10.1107/S2053230X14007250. (Journal Articles)
  • Oliver MR., Crowther JM., Leeman MM., Kessans SA., North RA., Donovan KA., Griffin MD., Suzuki H., Hudson AO. and Kasanmascheff M. (2014) The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana. Acta Crystallographica Section F: Structural Biology Communications 70(5): 663-668. http://dx.doi.org/10.1107/S2053230X14007699. (Journal Articles)
  • Kessans SA., Linhart MD., Matoba N. and Mor T. (2013) Biological and biochemical characterization of HIV-1 Gag/dgp41 virus-like particles expressed in Nicotiana benthamiana. Plant Biotechnology Journal 11(6): 681-690. http://dx.doi.org/10.1111/pbi.12058. (Journal Articles)
  • North RA., Kessans SA., Atkinson SC., Suzuki H., Watson AJA., Burgess BR., Angley LM., Hudson AO., Varsani AM. and Griffin DW. (2013) Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of N-acetyl neuraminate lyase from methicillin-resistant Staphylococcus aureus. Acta Cryst. 69(3): 306-312. http://dx.doi.org/10.1107/S1744309113003060. (Journal Articles)
  • Kessans SA., Frater J., Matoba N. and Mor T. (2009) P02-10. Plant expression of chimeric Gag/gp41 virus-like particles as a mucosally-targeted subunit vaccine against HIV-1. Retrovirology 6(SUPPL. 3) http://dx.doi.org/10.1186/1742-4690-6-S3-P15. (Journal Articles)
  • Kessans SA., Frater J., Matoba N. and Mor T. (2009) Plant expression of chimeric Gag/gp41 virus-like particles as a mucosally-targeted subunit vaccine against HIV-1. In RETROVIROLOGY 6 http://dx.doi.org/10.1186/1742-4690-6-S3-P15. (Conference Contributions - Published)
  • Matoba N., Cherni I., Kessans S., Frater J., Preston K., Bomsel M. and Mor TS. (2009) P12-16. Biochemical and immunological characterization of the plant-derived candidate HIV-1 mucosal vaccine CTB-MPR. Retrovirology 6(SUPPL. 3) http://dx.doi.org/10.1186/1742-4690-6-S3-P182. (Journal Articles)
  • Held MA., Penning B., Brandt AS., Kessans SA., Yong W., Scofield SR. and Carpita NC. (2008) Small-interfering RNAs from natural antisense transcripts derived from a cellulose synthase gene modulate cell wall biosynthesis in barley. Proceedings of the National Academy of Sciences of the United States of America 105(51): 20534-20539. http://dx.doi.org/10.1073/pnas.0809408105. (Journal Articles)
  • Ansari KI., Walter S., Brennan JM., Lemmens M., Kessans S., McGahern A., Egan D. and Doohan FM. (2007) Retrotransposon and gene activation in wheat in response to mycotoxigenic and non-mycotoxigenic-associated Fusarium stress. Theoretical and Applied Genetics 114(5): 927-937. http://dx.doi.org/10.1007/s00122-006-0490-0. (Journal Articles)
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