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Dr Constantine Zakkaroff

Contact

Department: Department of Accounting and Information Systems

Email: constantine.zakkaroff@canterbury.ac.nz

Direct Dial: +64 3 3693879

Office: Meremere 516

Languages: English, Polish, Russian

My teaching is focused on object-oriented systems development and data management. My research is in the area of large-scale physiological modelling.
About
Research / Creative works

Researcher Summary

Dr Zakkaroff is a researcher with experience in cardiovascular image analysis, medical image registration and visualisation. He received his BSc and MSc degrees in computer science from the University of Canterbury, New Zealand, and his PhD from the University of Leeds, United Kingdom. His current research interests are large scale physiological simulation, and high performance computing. Dr Zakkaroff is developing the Coupled Arterial Cells project. At its core, this project has a massively parallel, multi-scale framework for modelling paracrine signalling. The project focuses on the investigation of the relationship between micro-scale cellular dynamics and the resulting emergent macro-scale behaviour as it is exemplified by the growth of atherosclerotic plaques. This approach to the exploration of large-scale emergent behaviour is capable of providing invaluable insights into the onset of coronary heart disease. In silico simulations enable the rapid exploration and pruning of the parameter search space for the refinement and integration of micro-level models into biologically realistic macro-scale models. The in silico simulation provide the opportunity to perform physiological experiments which are impossible in the in vivo or in vitro settings.

Subject Area: Disciplines

  • Computer Science, Information Technology, Information Sciences: High Performance Computing (HPC); Information Systems; Software Engineering and Visualisation

Research/Scholarly/Creative Works

  • Dowding S., Plank MJ., Zakkaroff C. and David T. (2018) The astrocyte-neuron lactate shuttle’s role in neurovascular coupling. Queenstown: 36th International Australasian Winter Conference on Brain Research, 25 Aug 2018. (Conference Contributions - Other)
  • Dowding S., Zakkaroff C., Moore S. and David T. (2018) Coronary smooth muscle cell calcium dynamics: Effects of bifurcation angle on atheroprone conditions. Frontiers in Physiology 9(OCT) http://dx.doi.org/10.3389/fphys.2018.01528. (Journal Articles)
  • Kenny A., Zakkaroff C., Plank M. and David T. (2018) Massively parallel simulations of neurovascular coupling with extracellular diffusion. Journal of Computational Science 24: 116-124. http://dx.doi.org/10.1016/j.jocs.2017.07.001. (Journal Articles)
  • Zakkaroff C., Biglands JD., Greenwood JP., Plein S., Boyle RD., Radjenovic A. and Magee DR. (2018) Patient-specific coronary blood supply territories for quantitative perfusion analysis. Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization 6(2): 137-154. http://dx.doi.org/10.1080/21681163.2016.1192003. (Journal Articles)
  • Zakkaroff C., Moore S., Dowding S. and David T. (2017) 3D time-varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation. International Journal for Numerical Methods in Biomedical Engineering 33(2) e02786 http://dx.doi.org/10.1002/cnm.2786. (Journal Articles)
  • Dowding S., Zakkaroff C. and Johny JP. (2016) In Silico Simulations of In Vitro Vasodilation Experiments. In : 195-198. (Conference Contributions - Published)
  • Kenny A., Zakkaroff C. and David T. (2016) Massively Parallel Simulations of Neurovascular Coupling. In : 395-398. (Conference Contributions - Published)
  • Zakkaroff C., Biglands JD., Greenwood JP., Plein S., Boyle RD., Radjenovic A. and Magee DR. (2016) Investigation into diagnostic accuracy of common strategies for automated perfusion motion correction. Journal of Medical Imaging 3(2) 024002 http://dx.doi.org/10.1117/1.JMI.3.2.024002. (Journal Articles)
  • Zakkaroff C., Dowding S., Kenny A. and David T. (2016) Effect of Bifurcation Angles on Arterial Coupled Cell Dynamics: Massively Parallel Simulations. In : 240-243. (Conference Contributions - Published)
  • Zakkaroff C. and David T. (2015) Bifurcating Blood Vessel Quad Mesh Generation for Large-Scale Parallel Simulations. In. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) Registration of coronary MRA to DCE-MRI myocardial perfusion series improves diagnostic accuracy through the computation of patient-specific coronary supply territories: a CE-MARC sub-study. Journal of Cardiovascular Magnetic Resonance 16(Suppl 1) O25 http://dx.doi.org/10.1186/1532-429X-16-S1-O25. (Journal Articles)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) A comparison of methods for automated motion correction of DCE-MRI perfusion datasets evaluated in terms of diagnostic accuracy: a CE-MARC sub-study. In Journal of Cardiovascular Magnetic Resonance 16(Suppl 1): P206-P206. http://dx.doi.org/10.1186/1532-429X-16-S1-P206. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) A Comparison of Methods for Automated Motion Correction of DCE-MRI Perfusion Datasets Evaluated in Terms of Diagnostic Accuracy: A CE-MARC sub-study. In University of Canterbury. UC High Performance Computing. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) Automated registration of dynamic contrast enhanced DCE-MRI cardiac perfusion achieves comparable diagnostic accuracy to manual motion correction: a CE-MARC sub-study. In Journal of Cardiovascular Magnetic Resonance 16(Suppl 1) http://dx.doi.org/10.1186/1532-429X-16-S1-P344. (Conference Contributions - Published)
  • Zakkaroff C. (2013) Fusion of magnetic resonance coronary angiography and dynamic contrast-enhanced magnetic resonance cardiac perfusion series for patient-specific perfusion analysis and visualisation. Leeds, UK. University of Leeds. (Theses / Dissertations)
  • Zakkaroff C., Radjenovic A., Greenwood JP. and Magee D. (2012) Recovery of Slice Rotations with the Stack Alignment Transform in Cardiac MR Series. In. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Greenwood JP. and Magee D. (2012) Stack Alignment Transform for Misalignment Correction in Cardiac MR Cine Series. In. (Conference Contributions - Published)
  • Zakkaroff C., Magee D., Radjenovic A. and Boyle R. (2010) Mediated Spatiotemporal Registration of Cardiac DCE-MRI and Coronary MR Angiography. Beijing, China: Spatio-Temporal Image Analysis for Longitudinal and Time-Series Image Data workshop held in conjunction with Medical Image Computing and Computer-Assisted Interventions, 20-24 Sep 2010. (Conference Contributions - Other)
  • Zakkaroff C., Magee D., Radjenovic A. and Boyle R. (2010) Mediated Spatiotemporal Fusion of Multiple Cardiac Magnetic Resonance Datasets for Patient-specific Perfusion Analysis. In. (Conference Contributions - Published)
  • Mitrovic A., Martin B., Suraweera P., Zakharov K., Milik N., Holland J. and McGuigan N. (2009) ASPIRE: An Authoring System and Deployment Environment for Constraint-Based Tutors. International Journal on Artificial Intelligence in Education 19(2): 155-188. (Journal Articles)
  • Suraweera P., Mitrovic A., Martin B., Holland J., Milik N., Zakharov K. and McGuigan N. (2009) Using Ontologies to Author Constraint-Based Intelligent Tutoring Systems. In Dicheva D; Mizoguchi R; Greer J (Ed.), Semantic Web Technologies for E-Learning: 77-95. Amsterdam: IOS Press. (Chapters)
  • Zakharov K., Mitrovic A. and Johnston L. (2008) Towards Emotionally-Intelligent Pedagogical Agents. In Lecture Notes in Computer Science (LNCS) 5091,: 19-28. http://dx.doi.org/10.1007/978-3-540-69132-7_7. (Conference Contributions - Published)
  • Zakharov K., Mitrovic A. and Johnston L. (2007) Pedagogical Agents Trying on a Caring Mentor Role. In Frontiers in Artifical Intelligence and Applications 158: 59-66. (Conference Contributions - Published)
  • Mitrovic A., Suraweera P., Martin B., Zakharov K., Milik N. and Holland J. (2006) Authoring Constraint-Based Tutors in ASPIRE. In Lecture Notes in Computer Science (LNCS) 4053(Intelligent Tutoring Systems): 41-50. http://dx.doi.org/10.1007/11774303_5. (Conference Contributions - Published)
  • Zakharov K., Mitrovic A. and Ohlsson S. (2005) Feedback Micro-engineering in EER-Tutor. In : 718-725. (Conference Contributions - Published)

Research Groups

  • Centre for Inclusive Digital Enterprise @ UC Business School (CeIDE@UC, pronounced “seed”)
  • Emerging Technologies and 21st Century Commerce
  • Special Interest Group on Blockchain and Cryptocurrencies
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