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Dr Rachael Wood

Contact

Department: Chemical and Process Engineering

Email: rachael.wood@canterbury.ac.nz

Direct Dial: +64 3 3691504

Office: Link Rm 402

Language: English

Changing the face of medicine using Bioprocess Engineering principles
About
Research / Creative works
Methods & Equipment

Fields of Research

  • Spinal cord injury repair
  • Neurodegenerative Disorders
  • Gel drug delivery
  • Biodegradable fabricated medical devices
  • Cell modelling of Endometriosis
  • Cell modelling of traumatic brain injury

Researcher Summary

My research revolves around cell and gene therapy and regenerative medicine, looking in particular at Spinal Cord Injury. My work looks at utilising the body's own cells to reconnect the damaged neurons in the spinal cord aided by biodegradable microdevices.

This research tends to be very interdisciplinary and I have collaborations with Mechanical and Electrical Engineering as well as in the School of Biological Sciences which is supported through my membership in the Biomolecular Interaction Centre (BIC) here at UC. Further afield I work with engineers, scientists and doctors at Auckland University, University of Otago, as well as universities in Australia, the US and the UK.

Other research interests include modelling the invasion mechanism of endometriosis and the cellular changes that occur during traumatic brain injuries.

Subject Area: Disciplines

  • Engineering and Technology: Bioengineering; Bioprocess Engineering; Chemical & Process
  • Health and Health Sciences: Biomedical
  • Biology: Molecular, Cellular and Whole Organism Biology: Biomolecular Interactions; Cell Biology

Research/Scholarly/Creative Works

Journal Articles
  • Ellis K., Wood R. and Munro D. (2022) The Experiences of Endometriosis Patients with Diagnosis and Treatment in New Zealand. Frontiers in Global Women's Health.
  • Wood R., Durali P. and Wall I. (2020) Impact of dual cell co-culture and cell-conditioned media on yield and function of a human olfactory cell line for regenerative medicine. Bioengineering 7(2) http://dx.doi.org/10.3390/bioengineering7020037.
  • Santiago-Toledo G., Georgiou M., dos Reis J., Roberton VH., Valinhas A., Wood RC., Phillips JB., Mason C., Li D. and Li Y. (2019) Generation of c-MycERTAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications. Scientific Reports 9(1) http://dx.doi.org/10.1038/s41598-019-49315-6.
  • Georgiou M., Reis JND., Wood R., Esteban PP., Roberton V., Mason C., Li D., Li Y., Choi D. and Wall I. (2018) Bioprocessing strategies to enhance the challenging isolation of neuro-regenerative cells from olfactory mucosa. Scientific Reports 8(1) http://dx.doi.org/10.1038/s41598-018-32748-w.
Conference Contributions - Other
  • Hashemi A., Wood R., Dunn E. and Nock V. (2022) Directing differentiation of stem cells using cell-imprinted culture platforms. Leuven, Belgium: Micro and Nano Engineering (MNE) 2022, 19-23 Sep 2022.
  • Hsieh M. and Wood R. (2022) Manufacture of 3D printed microneedles for pharmacological drug delivery. Melbourne, Australia: 27th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering, 20-22 Apr 2022.
  • Hsieh M. and Wood R. (2022) Manufacture of 3D printed microneedles for pharmacological drug delivery. Melbourne, Australia: Chemeca 2022, 25-27 Sep 2022.
  • Jenkins D., Wood R. and Perez-Esteban P. (2022) Polymer micro-hollow fibre membranes for cell alignment in neural regeneration applications. Melbourne, Australia: 27th Conference of the Australian Society for Biomaterials and Tissue Engineering (ASBTE 2022), 20 Apr-22 Sep 2022.
  • Wood R., Georgiou M. and Wall I. (2022) Investigating the requirement for dual cell co-culture platforms in creating regenerative cell therapies for CNS injury. San Diego, CA, USA: Scale-up and Manufacturing of Cell-based Therapies V, 15-19 Jan 2017.
  • Wood R. and Wall I. (2019) Towards an allogeneic therapy for neural regeneration. Coronado, CA, USA: Advancing Manufacture of Cell and Gene Therapies VI, 27-31 Jan 2019.
  • Wood R., Santiago Toledo G. and Wall I. (2019) Towards an allogeneic therapy for neural regeneration. Barcelona, Spain: 6th Annual Symposium of Future Investigators of Regenerative Medicine (FIRM 2019), 23-26 Sep 2019.
  • Wood R., Georgiou M., dos Reis J. and Wall I. (2016) Investigating the Interaction between Olfactory Fibroblasts and Olfactory Ensheathing Cells in Co-Culture. London, UK: 16th Annual Meeting of the Tissue and Cell Engineering Society (TCES 2016), 4-6 Jul 2016.
  • Wood R., Georgiou M., dos Reis J. and Wall I. (2015) Investigating the Interaction between Olfactory Fibroblasts and Olfactory Ensheathing Cells in Co-Culture. Cambridge, UK: 12th Annual BioProcessUK Conference, 25-26 Nov 2015.
Oral Presentations
  • Wood R. (2021) Investigating the Use of Cell Therapy for Neural Regeneration in the Central Nervous System. Christchurch, New Zealand: Brain Date HealthTech, 24 Mar 2021.
Other
  • Hsieh M. and Wood R. (2022) Manufacture of 3D printed microneedles for pharmacological drug delivery. Health Research Society of Canterbury, Christchurch, New Zealand: [Poster Presentation].

Key Methodologies

  • Aseptic Mammalian Cell Culture
  • Fluorescent confocal microscopy
  • Mammalian cell characterisation
  • Functional cell testing
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