Research/Scholarly/Creative Works

• Bundela R., Keown J., Watkin S. and Pearce FG. (2019) Structure of a hyperthermostable dimeric archaeal rubisco from hyperthermus butylicus. Acta Crystallographica Section D: Structural Biology 75: 536-544. http://dx.doi.org/10.1107/S2059798319006466. (Journal Articles)

• Davies JS., Coombes D., Horne CR., Pearce FG., Friemann R., North RA. and Dobson RCJ. (2019) Functional and solution structure studies of amino sugar deacetylase and deaminase enzymes from Staphylococcus aureus. FEBS Letters 593(1): 52-66. http://dx.doi.org/10.1002/1873-3468.13289. (Journal Articles)

• Grant Pearce F. (2019) An unexpected sticking point for carboxysome assembly. Journal of Biological Chemistry 294(8): 2604-2605. http://dx.doi.org/10.1074/jbc.H119.007530. (Journal Articles)

• Clark S., Myers JB., King A., Fiala R., Novacek J., Pearce G., Heierhorst J., Reichow SL. and Barbar EJ. (2018) Erratum: Multivalency regulates activity in an intrinsically disordered transcription factor (eLife (2018) 7 PII: e40684). eLife 7 http://dx.doi.org/10.7554/eLife.40684. (Journal Articles)

• Clark S., Myers JB., King A., Fiala R., Novacek J., Pearce G., Heierhorst J., Reichow SL. and Barbar EJ. (2018) Multivalency regulates activity in an intrinsically disordered transcription factor. eLife 7 http://dx.doi.org/10.7554/eLife.36258. (Journal Articles)

• Keown JR., Black MM., Ferron A., Yap M., Barnett MJ., Grant Pearce F., Stoye JP. and Goldstone DC. (2018) A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5 and mammalian autophagy-related ATG8 proteins. Journal of Biological Chemistry 293(47): 18378-18386. http://dx.doi.org/10.1074/jbc.RA118.004202. (Journal Articles)

• Raynes JK., Domigan LJ., Pearce FG. and Gerrard JA. (2018) Immobilization of tobacco etch virus (TEV) protease on a high surface area protein nanofibril scaffold. Biotechnology Progress 34(6): 1506-1512. http://dx.doi.org/10.1002/btpr.2670. (Journal Articles)

• Ryan TM., Trewhella J., Murphy JM., Keown JR., Casey L., Pearce FG., Goldstone DC., Chen K., Luo Z. and Kobe B. (2018) An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis. Journal of Applied Crystallography 51: 97-111. http://dx.doi.org/10.1107/S1600576717017101. (Journal Articles)

• Valegård K., Andralojc PJ., Haslam RP., Pearce FG., Eriksen GK., Madgwick PJ., Kristoffersen AK., van Lun M., Klein U. and Eilertsen HC. (2018) Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications. Journal of Biological Chemistry 293(34): 13033-13043. http://dx.doi.org/10.1074/jbc.RA118.003518. (Journal Articles)

• Watkin SAJ., Keown JR., Richards E., Goldstone DC., Devenish SRA. and Grant Pearce F. (2018) Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly.. Biochem J 475(1): 137-150. http://dx.doi.org/10.1042/BCJ20170709. (Journal Articles)

• Yewdall NA., Allison TM., Pearce FG., Robinson CV. and Gerrard JA. (2018) Self-assembly of toroidal proteins explored using native mass spectrometry. Chemical Science 9(28): 6099-6106. http://dx.doi.org/10.1039/c8sc01379a. (Journal Articles)

• Yewdall NA., Peskin AV., Hampton MB., Goldstone DC., Pearce FG. and Gerrard JA. (2018) Quaternary structure influences the peroxidase activity of peroxiredoxin 3. Biochemical and Biophysical Research Communications 497(2): 558-563. http://dx.doi.org/10.1016/j.bbrc.2018.02.093. (Journal Articles)

• Domigan LJ., Ashmead H., Dimartino S., Malmstrom J., Pearce FG., Blunt M., Williams DE. and Gerrard JA. (2017) Formation of supramolecular protein structures on gold surfaces. Biointerphases 12(4) 04E405-1 http://dx.doi.org/10.1116/1.4986053. (Journal Articles)

• Fagerlund RD., Wilkinson ME., Klykov O., Barendregt A., Pearce FG., Kieper SN., Maxwell HWR., Capolupo A., Heck AJR. and Krause KL. (2017) Spacer capture and integration by a type I-F Cas1-Cas2-3 CRISPR adaptation complex. Proceedings of the National Academy of Sciences of the United States of America 114(26): E5122-E5128. http://dx.doi.org/10.1073/pnas.1618421114. (Journal Articles)

• Hudson AO., Savka MA., Pearce FG. and Dobson R. (2017) Lysine biosynthesis in microorganisms.. In D'Mello JPF (Ed.), The handbook of microbial metabolism of amino acids.CABI. http://dx.doi.org/10.1079/9781780647234.0049. (Chapters)

• Pearce FG., Hudson AO., Loomes K. and Dobson RCJ. (2017) Dihydrodipicolinate synthase: Structure, dynamics, function, and evolution. 83: 271-289. http://dx.doi.org/10.1007/978-3-319-46503-6_10. (Journal Articles)

• Pearce FG., Hudson AO., Loomes K. and Dobson RCJ. (2017) Dihydrodipicolinate synthase: Structure, dynamics, function, and evolution. In Harris JR; Marles-Wright J (Ed.), Macromolecular Protein Complexes: 271-289. Switzerland: Springer International. 10.1007/978-3-319-46503-6_10. (Chapters)

• Stevens AJ., Taylor MG., Pearce FG. and Kennedy MA. (2017) Allelic dropout during polymerase chain reaction due to G-quadruplex structures and DNA methylation is widespread at imprinted human loci. G3: Genes, Genomes, Genetics 7(3): 1019-1025. http://dx.doi.org/10.1534/g3.116.038687. (Journal Articles)

• Wason A., Pearce FG., Gerrard JA. and Mabbutt BC. (2017) Archaeal Lsm rings as stable self-assembling tectons for protein nanofabrication. Biochemical and Biophysical Research Communications 489(3): 326-331. http://dx.doi.org/10.1016/j.bbrc.2017.05.129. (Journal Articles)

• Watkin S., Pearce FG., Dobson R. and Nock VM. (2017) Developing New Microfluidic Tools for the Biochemistry Toolbox. Lorne, Australia: 42nd Lorne Conference on Protein Structure and Function, 5-8 Feb 2017. (Conference Contributions - Other)

• Watkin SAJ., Ryan TM., Miller AG., M. Nock V., Pearce FG. and Dobson RCJ. (2017) Microfluidics for Small-Angle X-ray Scattering. X-ray Scattering: 1-17. Rijeka: InTech. http://dx.doi.org/10.5772/65678. (Chapters)

• Chen K., Dobson RCJ., Lucet IS., Young SN., Pearce FG., Blewitt ME. and Murphy JM. (2016) The epigenetic regulator smchd1 contains a functional ghkl-type atpase domain. Biochemical Journal 473(12): 1733-1744. http://dx.doi.org/10.1042/BCJ20160189. (Journal Articles)

• Christensen JB., Soares Da Costa TP., Faou P., Pearce FG., Panjikar S. and Perugini MA. (2016) Structure and Function of Cyanobacterial DHDPS and DHDPR. Scientific Reports 6 http://dx.doi.org/10.1038/srep37111. (Journal Articles)

• Cree SL., Fredericks R., Miller A., Pearce FG., Filichev V., Fee C. and Kennedy MA. (2016) DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. FEBS Letters : 2870-2883. http://dx.doi.org/10.1002/1873-3468.12331. (Journal Articles)

• North RA., Watson AJA., Pearce FG., Muscroft-Taylor AC., Friemann R., Fairbanks AJ. and Dobson RCJ. (2016) Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus. FEBS Letters 590(23): 4414-4428. http://dx.doi.org/10.1002/1873-3468.12462. (Journal Articles)

• Keown JR. and Pearce FG. (2014) Characterization of spinach ribulose-1,5-bisphosphate carboxylase/oxygenase activase isoforms reveals hexameric assemblies with increased thermal stability. Biochemical Journal 464(3): 413-423. http://dx.doi.org/10.1042/BJ20140676. (Journal Articles)

• Phillips AJ., Littlejohn J., Yewdall NA., Zhu T., Valéry C., Pearce FG., Mitra AK., Radjainia M. and Gerrard JA. (2014) Peroxiredoxin is a versatile self-assembling tecton for protein nanotechnology. Biomacromolecules 15(5): 1871-1881. http://dx.doi.org/10.1021/bm500261u. (Journal Articles)

• Dogovski C., Gorman MA., Keteran NE., Praszkier J., Zammit LM., Mertens HD., Bryant G., Yang J., Griffin MDW. and Pearce FG. (2013) From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae. PLOS ONE 7(12) e83419 http://dx.doi.org/10.1371/journal.pone.0083419. (Journal Articles)

• Keown JR., Griffin MDW., Mertens HDT. and Pearce FG. (2013) Small oligomers of ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase are required for biological activity. Journal of Biological Chemistry 288: 20607-20615. http://dx.doi.org/10.1074/jbc.M113.466383. (Journal Articles)

• Pearce FG. (2013) How do enzyme dynamics influence rubisco activity? Advanced Topics in Science and Technology in China: 691-693. http://dx.doi.org/10.1007/978-3-642-32034-7_149. (Chapters)

• Atkinson SC., Dogovski C., Downton MT., Pearce FG., Reboul CF., Buckle AM., Gerrard JA., Dobson RCJ., Wagner J. and Perugini MA. (2012) Crystal, Solution and In silico Structural Studies of Dihydrodipicolinate Synthase from the Common Grapevine. PLoS ONE 7(6) e38318 http://dx.doi.org/10.1371/journal.pone.0038318. (Journal Articles)

• Griffin MDW., Billakanti JM., Wason A., Keller S., Mertens HDT., Atkinson SC., Dobson RCJ., Perugini MA., Gerrard JA. and Pearce FG. (2012) Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana. PLoS ONE 7(7) http://dx.doi.org/10.1371/journal.pone.0040318. (Journal Articles)

• Lassé M., Gerrard JA. and Pearce FG. (2012) Aggregation and fibrillogenesis of proteins not associated with disease: A few case studies. In Harris JR (Ed.), Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease: 253-270. Dordrecht/New York: Springer. http://dx.doi.org/10.1007/978-94-007-5416-4_11. (Chapters)

• Evans G., Schuldt L., Griffin MDW., Devenish SRA., Pearce FG., Perugini MA., Dobson RCJ., Jameson GB., Weiss MS. and Gerrard JA. (2011) A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics 512(2): 154-159. http://dx.doi.org/10.1016/j.abb.2011.05.014. (Journal Articles)

• Griffin MD., Billakanti JM., Gerrard JA., Dobson RCJ. and Pearce FG. (2011) Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana. Acta crystallographica Section F: Structural biology and crystallization communications 67(11): 1386-1390. http://dx.doi.org/10.1107/S1744309111033276. (Journal Articles)

• Pearce FG., Dobson RCJ., Jameson GB., Perugini MA. and Gerrard JA. (2011) Characterisation of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerisation. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1814(12): 1900-1909. http://dx.doi.org/10.1016/j.bbapap.2011.07.016. (Journal Articles)

• Raynes JK., Pearce FG., Meade SJ. and Gerrard JA. (2011) Immobilization of organophosphate hydrolase on an amyloid fibril nanoscaffold: Towards bioremediation and chemical detoxification. Biotechnology Progress 27(2): 360-367. http://dx.doi.org/10.1002/btpr.518. (Journal Articles)

• Dommaraju S., Gorman MA., Dogovski C., Pearce FG., Gerrard JA., Dobson RCJ., Parker MW. and Perugini MA. (2010) Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66(1): 57-60. http://dx.doi.org/10.1107/s1744309109047964. (Journal Articles)

• Muscroft-Taylor AC., Catchpole RJ., Dobson RCJ., Pearce FG., Perugini MA. and Gerrard JA. (2010) Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine. Archives of Biochemistry and Biophysics 503: 202-206. http://dx.doi.org/10.1016/j.abb.2010.08.009. (Journal Articles)

• Dommaraju SR., Gorman MA., Dogovski C., Pearce FG., Gerrard JA., Dobson RCJ., Parker MW. and Perugini MA. (2009) Cloning expression and crystallization of Dihydrodipicolinate reductase from Methicillin-resistant Staphylococcus aureus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66(1): 57-60. (Journal Articles)

• Pearce FG., Griffin MDW. and Gerrard JA. (2009) Does domain swapping improve the stability of RNase A? Biochemical and Biophysical Research Communications 382(1): 114-118. http://dx.doi.org/10.1016/j.bbrc.2009.02.142. (Journal Articles)

• Dobson RCJ., Griffin MDW., Devenish SRA., Pearce FG., Hutton CA., Gerrard JA., Jameson GB. and Perugini MA. (2008) Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase. Protein Science 17(12): 2080-2090. http://dx.doi.org/10.1110/ps.037440.108. (Journal Articles)

• Griffin MDW., Dobson RCJ., Pearce FG., Antonio L., Whitten AE., Liew CK., Mackay JP., Trewhella J., Jameson GB. and Perugini MA. (2008) Evolution of quaternary structure in a homotetrameric enzyme. Journal of Molecular Biology 380(4): 691-703. http://dx.doi.org/10.1016/j.jmb.2008.05.038. (Journal Articles)

• Kefala G., Evans GL., Griffin MDW., Devenish SRA., Pearce FG., Perugini MA., Gerrard JA., Weiss MS. and Dobson RCJ. (2008) Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis. Biochemical Journal 411(2): 351-360. http://dx.doi.org/10.1042/BJ20071360. (Journal Articles)

• Mitsakos V., Dobson RCJ., Pearce FG., Devenish SR., Evans GL., Burgess BR., Perugini MA., Gerrard JA. and Hutton CA. (2008) Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens? Bioorganic & Medicinal Chemistry Letters 18(2): 842-844. http://dx.doi.org/10.1016/j.bmcl.2007.11.026. (Journal Articles)

• Pearce FG., Dobson RCJ., Weber A., Lane LA., McCammon MG., Squire MA., Perugini MA., Jameson GB., Robinson CV. and Gerrard JA. (2008) Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: Toward a monomeric enzyme. Biochemistry 47(46): 12108-12117. http://dx.doi.org/10.1021/bi801094t. (Journal Articles)

• Pearce FG., Sprissler C. and Gerrard JA. (2008) Characterization of dihydrodipicolinate reductase from Thermotoga maritima reveals evolution of substrate binding kinetics. Journal of Biochemistry 143: 617-623. http://dx.doi.org/10.1093/jb/mvn012. (Journal Articles)

• Pearce FG., Mackintosh SH. and Gerrard JA. (2007) Formation of amyloid-like fibrils by ovalbumin and related proteins under conditions relevant to food processing. Journal of Agricultural and Food Chemistry 55(2): 318-322. http://dx.doi.org/10.1021/jf062154p. (Journal Articles)

• Devenish SRA., Dobson RCJ., Turner LA., Clifford VR., Pearce FG., Jameson GB. and Gerrard JA. (2006) The Role of Active Site Residue Arginine 138 in Dihydrodipicolinate Synthase. Auckland, New Zealand: 1st New Zealand Structural Biology Meeting, 18-19 Mar 2006. (Conference Contributions - Other)

• Evans GL., Devenish SRA., Dobson RCJ., Pearce FG. and Gerrard JA. (2006) Kinetic study of dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis. Lorne, Australia: 31st Annual Lorne Conference on Protein Structure and Function, 5-9 Feb 2006. (Conference Contributions - Other)

• Pearce FG. (2006) Catalytic by-product formation and ligand binding by ribulose bisphosphate carboxylases from different phylogenies. Biochemical Journal 399(3): 525-534. http://dx.doi.org/10.1042/BJ20060430. (Journal Articles)

• Pearce FG. and Andersson I. (2006) Photosynthesis in the Freezer - Crystallographic Studies of Rubisco from Arctic Diatoms. Auckland, New Zealand: 1st New Zealand Structural Biology Meeting, 18-19 Mar 2006. (Conference Contributions - Other)

• Pearce FG., Mackintosh SH. and Gerrard JA. (2006) Are Amyloid Fibrils Formed During Cooking? Lorne, Australia: 31st Annual Lorne Conference on Protein Structure and Function, 5-9 Feb 2006. (Conference Contributions - Other)

• Pearce FG., Perugini MA., McKerchar HJ. and Gerrard JA. (2006) Dihydrodipicolinate synthase from Thermotoga maritima. Biochemical Journal 400(2): 359-366. http://dx.doi.org/10.1042/BJ20060771. (Journal Articles)

• Walker SK., Pearce FG., Heinemann J. and Gerrard JA. (2006) Using Algorithms to Design Aggregating Proteins. Lorne, Australia: 31st Annual Lorne Conference on Protein Structure and Function, 5-9 Feb 2006. (Conference Contributions - Other)

• Dobson RCJ., Devenish SRA., Turner LA., Clifford VR., Pearce FG., Jameson GB. and Gerrard JA. (2005) Role of Arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase. Biochemistry 44: 13007-13013. (Journal Articles)

• Pearce FG. (2005) Rubisco & its quirky habits. School of Biological Sciences, University of Cante: Invitrogen SBS Seminar Series, 01 Jun 1998. (Oral Presentations)

• Pearce FG., McKerchar HJ. and Gerrard JA. (2005) Some Like it Hot - Studies of a Thermophillic Enzyme. Adelaide, Australia: ComBio 2005, 25 Sep 2005. (Conference Contributions - Other)

• Dobson RCJ., Gerrard JA. and Pearce FG. (2004) Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde. Biochemical Journal 377: 757-762. (Journal Articles)

• Dobson RCJ., Pearce FG. and Gerrard JA. (2004) Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate semialdehyde. Biochemical Journal 377: 757-762. (Journal Articles)

• Pearce F. (2004) Flame retardant shows up in Arctic. New Scientist 182(2451): 10-11. (Journal Articles)

• Pearce FG. (2003) Self-Inhibition of Rubisco by Inhibitory By-Products. Canberra, Australia. Australian National University. (Theses / Dissertations)

• Pearce FG. and Andrews TJ. (2003) Not All Rubiscos Are Created Equal. Melbourne, Australia: ComBio 2003, 28 Sep 2003. (Conference Contributions - Other)

• Pearce FG. and Andrews TJ. (2003) The Relationship between Side Reactions and Slow Inhibition of Ribulose-bisphosphate Carboxylase Revealed by a Loop 6 Mutant of the Tobacco Enzyme. Journal of Biological Chemistry 278(35): 32526-32536. (Journal Articles)

• Pearce FG., Whitney SM. and Andrews TJ. (2002) Why Doesn’t a Mutant Higher Plant Rubisco Show Fallover? South Hadley, MA, USA: Gordon Research Conference (GRC) on CO2 and Metabolism in Green Plants, 11 Aug 2002. (Conference Contributions - Other)

• Pearce FG., Andrews TJ., Kane HJ. and Whitney SM. (2001) A Mutation in Rubisco Reduces Fallover. Canberra, Australia: ComBio 2001, 30 Sep 2001. (Conference Contributions - Other)

• Pearce FG., Andrews TJ., Kane HJ., Sharwood RE. and Whitney SM. (2001) A Mutation in the Rubisco Large Subunit Reduces the Decline in Activity During Catalysis. Brisbane, Australia: 12th International Congress on Photosynthesis, 18 Aug 2001. In PS2001: Proceedings of the 12th International Congress on Photosynthesis online(http://www.publish.csiro.au/issue/1342.htm): 5pp. (Conference Contributions - Published)

• Gerrard JA., Dobson RCJ. and Pearce FG. (2000) Is dihydrodipicolinate inhibited by its substrate? Wellington, New Zealand: ComBio 2000, 11 Dec 2000. (Conference Contributions - Other)

Review and Refereeing

• Acta Crystallographica Section F ( 2000 - 2005)
• Australian Synchrotron ( 2010 - 2019)
• PLoS One; Proceedings of the National Academy of Sciences; Molecular Biosystems; New Zealand Journal of Botany; Acta Crystallographica F ( 2006 - 2019)

Research Groups