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+64 3 369 3999 ext. 95599
Julius von Haast 437
My research team seeks to understand the role of free radical mediated cellular damage in disease pathogenesis and how antioxidant metabolism modulates these processes. Our work has focused on describing how oxidized low density lipoprotein (LDL) triggers macrophage cells death within the artery wall and how the macrophage generated pterins, neopterin and 7,8-dihydroneopterin, modulate both oxLDL formation and cytotoxicity. We specialise in cell culture analysis, HPLC, and general biochemistry analysis using photometric and immune analysis. We also have an active program of biochemical and image analysis of excised atherosclerotic plaques. The image analysis has lead to the development of a multi-energy X-ray machine (MARS-CT) using the X-ray cameras developed for the Large Hadron Collider (LHC) in CERN Switzerland.