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Professor Tim David

Contact

Department: Mechanical Engineering ; UC High Performance Computing

Email: tim.david@canterbury.ac.nz

Direct Dial: +64 3 3692094

Office:

Language: English

Compared to most parts of our body if there's one thing we know virtually nothing about it's the brain.
About
Research / Creative works
Supervision
Networks
Methods & Equipment

Fields of Research

  • Mathematical and numerical models of cardiovascular blood flow
  • Neurovascular Coupling
  • Computational Physiology
  • Dynamics of Coupled Cells

Researcher Summary

Research interests include:
- Neurovascular coupling
- Dynamics of large vascular trees

Subject Area: Disciplines

  • Engineering and Technology: Bioengineering; Computer & Software Engineering
  • Health and Health Sciences: Biomedical
  • Biology: Molecular, Cellular and Whole Organism Biology: Cell Biology

Resources

  • Staff webpage
  • H-index profile
  • Brains Trust Research

Prizes and Awards

  • Institute of Mathematics and its Applications ( 1997 - 2002)
  • Institute of Physics and Engineering in Medicine ( 1997 - 2002)
  • IPENZ ( 2006 - 2021)

Research/Scholarly/Creative Works

(Displaying research/scholarly/creative work for last six years)
Journal Articles
  • Sun Y., Zhao D., Ni S., David T. and Zhang Y. (2020) Entropy and flame transfer function analysis of a hydrogen-fueled diffusion flame in a longitudinal combustor. Energy 194 http://dx.doi.org/10.1016/j.energy.2019.116870.
  • Hart JL., Gremaud PA. and David T. (2019) Global Sensitivity Analysis of High-Dimensional Neuroscience Models: An Example of Neurovascular Coupling. Bulletin of Mathematical Biology 81(6): 1805-1828. http://dx.doi.org/10.1007/s11538-019-00578-0.
  • Kenny A., Plank MJ. and David T. (2019) Minimal model of calcium dynamics in two heterogeneous coupled cells. Neurocomputing 323: 128-138. http://dx.doi.org/10.1016/j.neucom.2018.09.074.
  • Kenny A., Plank MJ. and David T. (2019) The effects of cerebral curvature on cortical spreading depression. Journal of Theoretical Biology 472: 11-26. http://dx.doi.org/10.1016/j.jtbi.2019.04.006.
  • Rashid U., Kumari N., Taylor D., David T. and Signal N. (2019) Gait Event Anomaly Detection and Correction during a Split-Belt Treadmill Task. IEEE Access 7: 68469-68478. http://dx.doi.org/10.1109/ACCESS.2019.2918559.
  • Dowding S., Zakkaroff C., Moore S. and David T. (2018) Coronary smooth muscle cell calcium dynamics: Effects of bifurcation angle on atheroprone conditions. Frontiers in Physiology 9(OCT) http://dx.doi.org/10.3389/fphys.2018.01528.
  • Kenny A., Plank MJ. and David T. (2018) Macro scale modelling of cortical spreading depression and the role of astrocytic gap junctions. Journal of Theoretical Biology 458: 78-91. http://dx.doi.org/10.1016/j.jtbi.2018.09.006.
  • Kenny A., Plank MJ. and David T. (2018) The role of astrocytic calcium and TRPV4 channels in neurovascular coupling. Journal of Computational Neuroscience 44(1): 97-114. http://dx.doi.org/10.1007/s10827-017-0671-7.
  • Kenny A., Zakkaroff C., Plank M. and David T. (2018) Massively parallel simulations of neurovascular coupling with extracellular diffusion. Journal of Computational Science 24: 116-124. http://dx.doi.org/10.1016/j.jocs.2017.07.001.
  • Mathias EJ., Kenny A., Plank MJ. and David T. (2018) Integrated models of neurovascular coupling and BOLD signals: Responses for varying neural activations. NeuroImage 174: 69-86. http://dx.doi.org/10.1016/j.neuroimage.2018.03.010.
  • Johny JP., Plank MJ. and David T. (2017) Importance of Altered Levels of SERCA, IP3R, and RyR in Vascular Smooth Muscle Cell. Biophysical Journal 112(2): 265-287. http://dx.doi.org/10.1016/j.bpj.2016.11.3206.
  • Mathias EJ., Plank MJ. and David T. (2017) A model of neurovascular coupling and the BOLD response PART II. Computer Methods in Biomechanics and Biomedical Engineering 20(5): 519-529. http://dx.doi.org/10.1080/10255842.2016.1255733.
  • Mathias EJ., Plank MJ. and David T. (2017) A model of neurovascular coupling and the BOLD response: PART I. Computer Methods in Biomechanics and Biomedical Engineering 20(5): 508-518. http://dx.doi.org/10.1080/10255842.2016.1255732.
  • Zakkaroff C., Moore S., Dowding S. and David T. (2017) 3D time-varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation. International Journal for Numerical Methods in Biomedical Engineering 33(2) e02786 http://dx.doi.org/10.1002/cnm.2786.
  • Dormanns K., Brown RG. and David T. (2016) The role of nitric oxide in neurovascular coupling. Journal of Theoretical Biology 394: 1-17. http://dx.doi.org/10.1016/j.jtbi.2016.01.009.
  • Schluter PJ., Ahuriri-Driscoll A., Anderson TJ., Beere P., Brown J., Dalrymple-Alford J., David T., Davidson A., Gillon DA. and Hirdes J. (2016) Comprehensive clinical assessment of home-based older persons within New Zealand: an epidemiological profile of a national cross-section. Australian and New Zealand Journal of Public Health 40(4): 349-355. http://dx.doi.org/10.1111/1753-6405.12525.
  • de Lancea CL., David T., Alastruey JM. and Brown RG. (2015) Recruitment Pattern in a Complete Cerebral Arterial Circle. Journal of Biomechanical Engineering 137(11) 111004: 11pp. http://dx.doi.org/10.1115/1.4031469.
  • Dormanns K., Brown RG. and David T. (2015) Neurovascular coupling: A parallel implementation. Frontiers in Computational Neuroscience 9 109: 17. http://dx.doi.org/10.3389/fncom.2015.00109.
  • Dormanns K., Brown RG. and David T. (2015) Neurovascular coupling: a parallel implementation. Frontiers in Computational Neuroscience 9 109: 17. http://dx.doi.org/10.3389/fncom.2015.00109.
  • Dormanns K., van Disseldorp EMJ., Brown RG. and David T. (2015) Neurovascular Coupling and the Influence of Luminal Agonists via the Endothelium. Journal of Theoretical Biology 364: 49-70. http://dx.doi.org/10.1016/j.jtbi.2014.08.029.
Conference Contributions - Published
  • David T., Alzaidi S. and Farr H.. (2020) Computational models of functional hyperaemia in the cerebro-vasculature. In 18th World IMACS Congress and MODSIM 2009 - International Congress on Modelling and Simulation: Interfacing Modelling and Simulation with Mathematical and Computational Sciences, Proceedings: 656-663.
  • Shaikh MA., David T. and Wall DJN.. (2020) Effects of spatially varying agonist concentration on calcium signalling in coupled vascular endothelial and smooth muscle cells. In 18th World IMACS Congress and MODSIM 2009 - International Congress on Modelling and Simulation: Interfacing Modelling and Simulation with Mathematical and Computational Sciences, Proceedings: 627-633.
  • Kenny A., Zakkaroff C. and David T.. (2016) Massively Parallel Simulations of Neurovascular Coupling. In : 395-398.
  • Zakkaroff C., Dowding S., Kenny A. and David T.. (2016) Effect of Bifurcation Angles on Arterial Coupled Cell Dynamics: Massively Parallel Simulations. In : 240-243.
  • Zakkaroff C., Dowding S., Kenny A. and David T.. (2016) In silico simulations of vasodilation. In : 195-198.
Conference Contributions - Other
  • Kenny A., David T. and Plank MJ. (2017) Neurovascular coupling and the BOLD response: Multiscale tissue slice simulations. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 26 Aug 2017.
  • Mathias E., Plank MJ. and David T. (2017) Simulated BOLD responses for neural activities such as continuous spiking, bursting and cortical spreading depression. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 26 Aug 2017.
  • van Ginkel T., David T. and Plank MJ. (2017) Detailed modelling of neuronal calcium spiking dynamics. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 26 Aug 2017.
  • Goodman M., David T., Docherty PD. and Murray R. (2016) Calcium Dynamics in Coupled Cellular Reaction Diffusion Equations. Queenstown, New Zealand: 34th Australasian Winter Conference on Brain Research, 27-31 Aug 2016.
  • Goodman M., David T., Docherty PD. and Murray R. (2016) Homogenisation Theory Applied to Coupled Mammalian Cells. Christchurch, New Zealand: Health Research Society of Canterbury: Christchurch Hospitals' Grand Rounds series 2016, 27-27 May 2016.
  • Goodman M., Murray R., Docherty PD. and David T. (2016) Homogenisation Theory with Coupled Cellular Reaction Diffusion Equations. Boston, MA, USA: SIAM Conference on the Life Sciences 2016, 11-14 Jul 2016.
  • Kenny A., David T. and Plank MJ. (2016) Massively parallel simulations of neurovascular coupling with nitric oxide pathway and extracellular diffusion. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 27-31 Aug 2016.
  • van Ginkel T., David T. and Plank M. (2016) Detailed modelling of neuronal calcium dynamics to enable validation of the NVU. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 27-31 Aug 2016.
  • Joel E., Plank MJ. and David T. (2015) Physiological models of neurovascular coupling and the relationship to BOLD signals in the ageing brain. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 29 Aug-2 Sep 2015.
Additional Publications
  • Kwak D., Ciris K. and David T. (2015) Computational Models of Cerebral Blood Flow under Altered Gravity.NASA. Commissioned by NASA.

Student Supervision

Displaying all items.
    Current
  • PhD - de Lancea C: 1D models of the Circle of Willis (2016)
  • PhD - Dormanns K: Neurovascular Coupling (2016)
  • PhD - Goodman M: Dynamics of Coupled Cells (2017)
  • PhD - Kenny A: Parallel Simulations of Neurovascular Coupling (2019)
  • PhD - Mathias E: Neurovascular Coupling and the BOLD signal (2016)
  • PhD - PhillipaJohny J: Role of variations in IP3R and RyR in SMC dynamics (2016)
  • PhD - van Ginkel T: Calcium Dynamics in the Neuron (2019)
  • Masters - Dowding S: Coupled Cells in the formation of atheroscerosis (2017)
  • Masters - Kenny A: Calcium Dynamics and Wave Propagation in Coupled Cells (2016)
  • Completed
  • PhD - Goodman M: Homogenisation Theory Applied to Coupled Mammalian Cells (2018)
  • Masters - Shek J: Homogenised models of smooth muscle and endothelial cells (2013)
  • Honours - Mugford J: Coupled cell dynamics (2013)

Editorial Work

Displaying all items.
  • ASME Journal of Biomechanical Engineering Associate Editor ( 2011 - 2017)
  • Computer Methods in Biomechanics and Biomedical Engineering Editorial Board Member ( 1997 - 2012)
  • International Journal of Experimental and Computational Biomechanics (IJECB) Editorial Board Member ( 2009 - 2021)
  • Journal of Biomechanics Editorial Board Member ( 2003 - 2012)
  • Journal of Biomedical Science and Engineering Editorial Board Member ( 2010 - 2021)
  • Medical Engineering and Physics Editorial Board Member ( 1997 - 2007)

Affiliations

  • Institute of Physics and Engineering in Medicine (IPEM) (Professional Organisation): Fellow (FIPEM)
  • Institution of Professional Engineers New Zealand (IPENZ) (Professional Organisation): Fellow
  • Royal Society of New Zealand (RSNZ) (Professional Organisation): Member

Research Groups

  • Biomathematics Research Centre
  • Centre for Bioengineering
  • The New Zealand Health and Ageing Research Group

Key Methodologies

  • - Massively parallel model of calcium dynamics in arterial structures
  • - Neurovascular coupling
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