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Professor Tim David

Contact

Department: Mechanical Engineering

Email: tim.david@canterbury.ac.nz

Direct Dial: +64 3 3692094

Office:

Language: English

Compared to most parts of our body if there's one thing we know virtually nothing about it's the brain.
About
Research / Creative works
Supervision
Networks
Methods & Equipment

Fields of Research

  • Mathematical and numerical models of cardiovascular blood flow
  • Neurovascular Coupling
  • Computational Physiology
  • Dynamics of Coupled Cells

Researcher Summary

Research interests include:
- Neurovascular coupling
- Dynamics of large vascular trees

Subject Area: Disciplines

  • Engineering and Technology: Bioengineering; Computer & Software Engineering
  • Health and Health Sciences: Biomedical
  • Biology: Molecular, Cellular and Whole Organism Biology: Cell Biology

Resources

  • Staff webpage
  • H-index profile

Prizes and Awards

  • Institute of Mathematics and its Applications ( 1997 - 2002)
  • Institute of Physics and Engineering in Medicine ( 1997 - 2002)
  • IPENZ ( 2006 - present )

Research/Scholarly/Creative Works

(Displaying research/scholarly/creative work for last six years)
Journal Articles
  • David T., Morillo R., Howarth C., Berwick J. and Lee L. (2023) The Reversal Characteristics of GABAergic Neurons: A Neurovascular Model. Journal of biomechanical engineering 145(3) http://dx.doi.org/10.1115/1.4056336.
  • Sun Y., Zhao D., Ni S., David T. and Zhang Y. (2020) Entropy and flame transfer function analysis of a hydrogen-fueled diffusion flame in a longitudinal combustor. Energy 194 http://dx.doi.org/10.1016/j.energy.2019.116870.
  • Hart JL., Gremaud PA. and David T. (2019) Global Sensitivity Analysis of High-Dimensional Neuroscience Models: An Example of Neurovascular Coupling. Bulletin of Mathematical Biology 81(6): 1805-1828. http://dx.doi.org/10.1007/s11538-019-00578-0.
  • Kenny A., Plank MJ. and David T. (2019) Minimal model of calcium dynamics in two heterogeneous coupled cells. Neurocomputing 323: 128-138. http://dx.doi.org/10.1016/j.neucom.2018.09.074.
  • Kenny A., Plank MJ. and David T. (2019) The effects of cerebral curvature on cortical spreading depression. Journal of Theoretical Biology 472: 11-26. http://dx.doi.org/10.1016/j.jtbi.2019.04.006.
  • Rashid U., Kumari N., Taylor D., David T. and Signal N. (2019) Gait Event Anomaly Detection and Correction during a Split-Belt Treadmill Task. IEEE Access 7: 68469-68478. http://dx.doi.org/10.1109/ACCESS.2019.2918559.
  • Dowding S., Zakkaroff C., Moore S. and David T. (2018) Coronary smooth muscle cell calcium dynamics: Effects of bifurcation angle on atheroprone conditions. Frontiers in Physiology 9(OCT) http://dx.doi.org/10.3389/fphys.2018.01528.
  • Kenny A., Plank MJ. and David T. (2018) Macro scale modelling of cortical spreading depression and the role of astrocytic gap junctions. Journal of Theoretical Biology 458: 78-91. http://dx.doi.org/10.1016/j.jtbi.2018.09.006.
  • Kenny A., Plank MJ. and David T. (2018) The role of astrocytic calcium and TRPV4 channels in neurovascular coupling. Journal of Computational Neuroscience 44(1): 97-114. http://dx.doi.org/10.1007/s10827-017-0671-7.
  • Kenny A., Zakkaroff C., Plank M. and David T. (2018) Massively parallel simulations of neurovascular coupling with extracellular diffusion. Journal of Computational Science 24: 116-124. http://dx.doi.org/10.1016/j.jocs.2017.07.001.
  • Mathias EJ., Kenny A., Plank MJ. and David T. (2018) Integrated models of neurovascular coupling and BOLD signals: Responses for varying neural activations. NeuroImage 174: 69-86. http://dx.doi.org/10.1016/j.neuroimage.2018.03.010.
  • Johny JP., Plank MJ. and David T. (2017) Importance of Altered Levels of SERCA, IP3R, and RyR in Vascular Smooth Muscle Cell. Biophysical Journal 112(2): 265-287. http://dx.doi.org/10.1016/j.bpj.2016.11.3206.
  • Mathias EJ., Plank MJ. and David T. (2017) A model of neurovascular coupling and the BOLD response PART II. Computer Methods in Biomechanics and Biomedical Engineering 20(5): 519-529. http://dx.doi.org/10.1080/10255842.2016.1255733.
  • Mathias EJ., Plank MJ. and David T. (2017) A model of neurovascular coupling and the BOLD response: PART I. Computer Methods in Biomechanics and Biomedical Engineering 20(5): 508-518. http://dx.doi.org/10.1080/10255842.2016.1255732.
  • Zakkaroff C., Moore S., Dowding S. and David T. (2017) 3D time-varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation. International Journal for Numerical Methods in Biomedical Engineering 33(2) e02786 http://dx.doi.org/10.1002/cnm.2786.
Conference Contributions - Other
  • Kenny A., David T. and Plank MJ. (2017) Neurovascular coupling and the BOLD response: Multiscale tissue slice simulations. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 26 Aug 2017.
  • Mathias E., Plank MJ. and David T. (2017) Simulated BOLD responses for neural activities such as continuous spiking, bursting and cortical spreading depression. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 26 Aug 2017.
  • van Ginkel T., David T. and Plank MJ. (2017) Detailed modelling of neuronal calcium spiking dynamics. Queenstown, New Zealand: International Australasian Winter Conference on Brain Research, 26 Aug 2017.

Student Supervision

Displaying all items.
    Current
  • PhD - de Lancea C: 1D models of the Circle of Willis (2016)
  • PhD - Dormanns K: Neurovascular Coupling (2016)
  • PhD - Goodman M: Dynamics of Coupled Cells (2017)
  • PhD - Kenny A: Parallel Simulations of Neurovascular Coupling (2019)
  • PhD - Mathias E: Neurovascular Coupling and the BOLD signal (2016)
  • PhD - PhillipaJohny J: Role of variations in IP3R and RyR in SMC dynamics (2016)
  • PhD - van Ginkel T: Calcium Dynamics in the Neuron (2019)
  • Masters - Dowding S: Coupled Cells in the formation of atheroscerosis (2017)
  • Masters - Kenny A: Calcium Dynamics and Wave Propagation in Coupled Cells (2016)
  • Completed
  • PhD - Goodman M: Homogenisation Theory Applied to Coupled Mammalian Cells (2018)
  • Masters - Shek J: Homogenised models of smooth muscle and endothelial cells (2013)
  • Honours - Mugford J: Coupled cell dynamics (2013)

Editorial Work

Displaying all items.
  • ASME Journal of Biomechanical Engineering Associate Editor ( 2011 - 2017)
  • Computer Methods in Biomechanics and Biomedical Engineering Editorial Board Member ( 1997 - 2012)
  • International Journal of Experimental and Computational Biomechanics (IJECB) Editorial Board Member ( 2009 - 2023)
  • Journal of Biomechanics Editorial Board Member ( 2003 - 2012)
  • Journal of Biomedical Science and Engineering Editorial Board Member ( 2010 - 2023)
  • Medical Engineering and Physics Editorial Board Member ( 1997 - 2007)

Affiliations

  • Institute of Physics and Engineering in Medicine (IPEM) (Professional Organisation): Fellow (FIPEM)
  • Institution of Professional Engineers New Zealand (IPENZ) (Professional Organisation): Fellow
  • Royal Society of New Zealand (RSNZ) (Professional Organisation): Member

Research Groups

  • Biomathematics Research Centre
  • Centre for Bioengineering
  • The New Zealand Health and Ageing Research Group

Key Methodologies

  • - Massively parallel model of calcium dynamics in arterial structures
  • - Neurovascular coupling
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